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@article{966062,
author = {Hapala, Jan and Trifonov, Eduard},
article_number = {1},
doi = {http://dx.doi.org/10.1016/j.gene.2011.08.022},
keywords = {AG-ends of introns; Gene splicing; GT-ends of introns; Nucleosome mapping; Protection of splice junctions; Rotational positioning},
language = {eng},
issn = {0378-1119},
journal = {Gene},
title = {High resolution positioning of intron ends on the nucleosomes},
volume = {489},
year = {2011}
}
TY - JOUR
ID - 966062
AU - Hapala, Jan - Trifonov, Eduard
PY - 2011
TI - High resolution positioning of intron ends on the nucleosomes
JF - Gene
VL - 489
IS - 1
SP - 6-10
EP - 6-10
PB - Elsevier
SN - 03781119
KW - AG-ends of introns
KW - Gene splicing
KW - GT-ends of introns
KW - Nucleosome mapping
KW - Protection of splice junctions
KW - Rotational positioning
N2 - High resolution sequence-directed nucleosome mapping is applied to 36,000 sequences containing splice junctions, from five different species.Moreover, the orientation of guanine residues at the GT- and AG-ends of introns within the nucleosomes is such that the guanines are positioned nearest to the surface of histone octamers, 3 and 4 bases upstream from the local DNA pseudo-dyads passing through minor grooves oriented outwards. Since the guanine residues are the most vulnerable to spontaneous damage within the cell (primarily, depurination and oxidation) such positioning of the splice junctions minimizes the damage that is caused by free radicals and highly reactive metabolites.
ER -
HAPALA, Jan a Eduard TRIFONOV. High resolution positioning of intron ends on the nucleosomes. \textit{Gene}. Elsevier, 2011, roč.~489, č.~1, s.~6-10. ISSN~0378-1119. Dostupné z: https://dx.doi.org/10.1016/j.gene.2011.08.022.
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