Early morphogenesis of heterodont dentition in minipigs

J 2010

Early morphogenesis of heterodont dentition in minipigs

ŠTEMBÍREK, Jan, Marcela BUCHTOVÁ, Tomáš KRÁL, Eva MATALOVÁ, Scott LOZANOFF et. al.

Basic information

Original name

Early morphogenesis of heterodont dentition in minipigs

Authors

ŠTEMBÍREK, Jan (203 Czech Republic, guarantor, belonging to the institution), Marcela BUCHTOVÁ (203 Czech Republic, belonging to the institution), Tomáš KRÁL (203 Czech Republic, belonging to the institution), Eva MATALOVÁ (203 Czech Republic, belonging to the institution), Scott LOZANOFF (840 United States of America) and Ivan MÍŠEK (203 Czech Republic)

Edition

EUROPEAN JOURNAL OF ORAL SCIENCES, 2010, 0909-8836

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30200 3.2 Clinical medicine

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 1.890

RIV identification code

RIV/00216224:14110/10:00055073

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1111/j.1600-0722.2010.00772.x

UT WoS

000284319400002

Keywords in English

dental lamina; epithelial pearls; odontogenesis; three-dimensional reconstruction

Abstract

V originále

The minipig provides an excellent experimental model for tooth morphogenesis because its diphyodont and heterodont dentition resemble that of humans. However, little information is available on the processes of tooth development in the pig. The purpose of this study was to classify the early stages of odontogenesis in minipigs from the initiation of deciduous dentition to the late bell stage when the successional dental lamina begins to develop. To analyze the initiation of teeth anlagens and the structural changes of dental lamina, a three-dimensional (3D) analysis was performed. At the earliest stage, 3D reconstruction revealed a continuous dental lamina along the length of the jaw. Later, the dental lamina exhibited remarkable differences in depth, and the interdental lamina was shorter. The dental lamina grew into the mesenchyme in the lingual direction, and its inclined growth was underlined by asymmetrical cell proliferation. After the primary tooth germ reached the late bell stage, the dental lamina began to disintegrate and fragmentize. Some cells disappeared during the process of lamina degradation, while others remained in small islands known as epithelial pearls. The minipig can therefore, inter alia, be used as a model organism to study the fate of epithelial pearls from their initiation to their contribution to pathological structures, primarily because of the clinical significance of these epithelial rests.

Citovat

ŠTEMBÍREK, Jan, Marcela BUCHTOVÁ, Tomáš KRÁL, Eva MATALOVÁ, Scott LOZANOFF and Ivan MÍŠEK. Early morphogenesis of heterodont dentition in minipigs. EUROPEAN JOURNAL OF ORAL SCIENCES. 2010, vol. 118, No 6, p. 547-558. ISSN 0909-8836. Available from: https://dx.doi.org/10.1111/j.1600-0722.2010.00772.x.

@article{967233,
   author = {Štembírek, Jan and Buchtová, Marcela and Král, Tomáš and Matalová, Eva and Lozanoff, Scott and Míšek, Ivan},
   article_number = {6},
   doi = {http://dx.doi.org/10.1111/j.1600-0722.2010.00772.x},
   keywords = {dental lamina; epithelial pearls; odontogenesis; three-dimensional reconstruction},
   language = {eng},
   issn = {0909-8836},
   journal = {EUROPEAN JOURNAL OF ORAL SCIENCES},
   title = {Early morphogenesis of heterodont dentition in minipigs},
   volume = {118},
   year = {2010}
}

TY  - JOUR
ID  - 967233
AU  - Štembírek, Jan - Buchtová, Marcela - Král, Tomáš - Matalová, Eva - Lozanoff, Scott - Míšek, Ivan
PY  - 2010
TI  - Early morphogenesis of heterodont dentition in minipigs
JF  - EUROPEAN JOURNAL OF ORAL SCIENCES
VL  - 118
IS  - 6
SP  - 547-558
EP  - 547-558
SN  - 09098836
KW  - dental lamina
KW  - epithelial pearls
KW  - odontogenesis
KW  - three-dimensional reconstruction
N2  - The minipig provides an excellent experimental model for tooth morphogenesis because its diphyodont and heterodont dentition resemble that of humans. However, little information is available on the processes of tooth development in the pig. The purpose of this study was to classify the early stages of odontogenesis in minipigs from the initiation of deciduous dentition to the late bell stage when the successional dental lamina begins to develop. To analyze the initiation of teeth anlagens and the structural changes of dental lamina, a three-dimensional (3D) analysis was performed. At the earliest stage, 3D reconstruction revealed a continuous dental lamina along the length of the jaw. Later, the dental lamina exhibited remarkable differences in depth, and the interdental lamina was shorter. The dental lamina grew into the mesenchyme in the lingual direction, and its inclined growth was underlined by asymmetrical cell proliferation. After the primary tooth germ reached the late bell stage, the dental lamina began to disintegrate and fragmentize. Some cells disappeared during the process of lamina degradation, while others remained in small islands known as epithelial pearls. The minipig can therefore, inter alia, be used as a model organism to study the fate of epithelial pearls from their initiation to their contribution to pathological structures, primarily because of the clinical significance of these epithelial rests.
ER  -

ŠTEMBÍREK, Jan, Marcela BUCHTOVÁ, Tomáš KRÁL, Eva MATALOVÁ, Scott LOZANOFF and Ivan MÍŠEK. Early morphogenesis of heterodont dentition in minipigs. \textit{EUROPEAN JOURNAL OF ORAL SCIENCES}. 2010, vol.~118, No~6, p.~547-558. ISSN~0909-8836. Available from: https://dx.doi.org/10.1111/j.1600-0722.2010.00772.x.

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