| BASAK, Grzegorz W., Ozren JAKSIC, Zdeněk KOŘÍSTEK, Gabor MIKALA, Sandra BASIC-KINDA, Jiří MAYER, Tamas MASSZI, Sebastian GIEBEL, Boris LABAR a Wieslaw WIKTOR-JEDRZEJCZAK. Haematopoietic stem cell mobilization with plerixafor and G-CSF in patients with multiple myeloma transplanted with autologous stem cells. European Journal of Haematology. 2011, roč. 86, č. 6, s. 488-495. ISSN 0902-4441. Dostupné z: https://dx.doi.org/10.1111/j.1600-0609.2011.01605.x. |
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@article{967795,
author = {Basak, Grzegorz W. and Jaksic, Ozren and Kořístek, Zdeněk and Mikala, Gabor and BasicandKinda, Sandra and Mayer, Jiří and Masszi, Tamas and Giebel, Sebastian and Labar, Boris and WiktorandJedrzejczak, Wieslaw},
article_number = {6},
doi = {http://dx.doi.org/10.1111/j.1600-0609.2011.01605.x},
keywords = {plerixafor; stem cell mobilization; myeloma; autologous stem cell transplantation},
language = {eng},
issn = {0902-4441},
journal = {European Journal of Haematology},
title = {Haematopoietic stem cell mobilization with plerixafor and G-CSF in patients with multiple myeloma transplanted with autologous stem cells},
volume = {86},
year = {2011}
}
TY - JOUR
ID - 967795
AU - Basak, Grzegorz W. - Jaksic, Ozren - Kořístek, Zdeněk - Mikala, Gabor - Basic-Kinda, Sandra - Mayer, Jiří - Masszi, Tamas - Giebel, Sebastian - Labar, Boris - Wiktor-Jedrzejczak, Wieslaw
PY - 2011
TI - Haematopoietic stem cell mobilization with plerixafor and G-CSF in patients with multiple myeloma transplanted with autologous stem cells
JF - European Journal of Haematology
VL - 86
IS - 6
SP - 488-495
EP - 488-495
SN - 09024441
KW - plerixafor
KW - stem cell mobilization
KW - myeloma
KW - autologous stem cell transplantation
N2 - A proportion of patients with multiple myeloma (MM) who have already undergone autologous stem cell transplantation (autoSCT) might benefit from a further transplantation. For this, they might need to undergo another round of stem cell mobilization. We analyzed retrospectively the outcomes of stem cell mobilization with plerixafor and granulocyte colony-stimulating factor (G-CSF) in a group of 30 patients who had undergone autoSCT previously, and in 46 other patients. The previously transplanted patients were significantly different from the remaining patients with respect to the intensity and number of previous therapies. We observed that the median peripheral blood concentration of CD34+ cells after the first administration of plerixafor was lower in previously transplanted (19 cells/mu L) than in other patients (30 cells/mu L). Despite a comparable number of apheresis sessions being performed, the median total yield of CD34+ cells was significantly lower in the previously transplanted than in the remaining patients (2.8 x 106 cells/kg vs. 4.2 x 106 cells/kg). However, successful collection of at least 2.0 x 106 CD34+ cells/kg was achieved finally in a similar proportion of previously transplanted and other patients (70% vs. 82.6%). Our data suggest that stem cell mobilization with plerixafor and G-CSF might overcome the negative effect of prognostic factors for poor stem cell mobilization in patients with MM who have undergone autoSCT previously.
ER -
BASAK, Grzegorz W., Ozren JAKSIC, Zdeněk KOŘÍSTEK, Gabor MIKALA, Sandra BASIC-KINDA, Jiří MAYER, Tamas MASSZI, Sebastian GIEBEL, Boris LABAR a Wieslaw WIKTOR-JEDRZEJCZAK. Haematopoietic stem cell mobilization with plerixafor and G-CSF in patients with multiple myeloma transplanted with autologous stem cells. \textit{European Journal of Haematology}. 2011, roč.~86, č.~6, s.~488-495. ISSN~0902-4441. Dostupné z: https://dx.doi.org/10.1111/j.1600-0609.2011.01605.x.
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