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@article{967807, author = {Čundrle, Ivan and Šrámek, Vladimír and Pavlík, Martin and Suk, Pavel and Radoušková, Iveta and Zvoníček, Václav}, article_number = {5}, keywords = {thromboelastography; cardiopulmonary resuscitaction}, language = {eng}, issn = {1214-2158}, journal = {Anesteziologie a intenzivní medicína}, title = {The influence of temperature adjustment on thromboelastography results: prospectíve cohort study}, volume = {22}, year = {2011} }
TY - JOUR ID - 967807 AU - Čundrle, Ivan - Šrámek, Vladimír - Pavlík, Martin - Suk, Pavel - Radoušková, Iveta - Zvoníček, Václav PY - 2011 TI - The influence of temperature adjustment on thromboelastography results: prospectíve cohort study JF - Anesteziologie a intenzivní medicína VL - 22 IS - 5 SP - 253-259 EP - 253-259 SN - 12142158 KW - thromboelastography KW - cardiopulmonary resuscitaction N2 - Thromboelastography (TEG) and standard coagulation tests are carried out at a laboratory temperature of 37C, thus omitting the effects of reál blood temperature.The aim of this study was comparing the results of kaolin - heparinase TEG and Rapid TEG during mild therapeutic hypothermia i.e. when the blood was analysed at the actual temperature (isothermia) and at 37C (normothermia).The second aim was to evaluate the clinical relevance of the results and on their basis to determine the necessity to analyse TEG at the actual temperature. Thirty patients following CPR (cardiopulmonary resuscitation), where therapeutic hypothermia (32-34C) was indicated for 24 hours, were included in the study.The patients were observed for 36 hours, and the TEG measurements were taken in 12-hour intervals. Standard coagulation tests, blood count, the dose of anticoagulants/antiaggregants, bleeding complications and changes in treatment according to TEG results were monítored. Data is shown as median (IQR).The Wilcoxon match pair test was used for the statistical analysis was considered significant. In hypothermic kaolin-heparinase TEG, all parameters describing clot formation (R, K, Angle, TMA and ČI) were significantly different from those measured at 37C. Clot strength parameters (MA, G) did not differ. In Rapid TEG, the differences between hypothermia and normotermia were less pro-nounced. There were mostly minor signs of bleeding only and clinical judgement was not influenced by the difference in TEG measurements. Statistically significant differences in TEG results were more pronounced in kaolin-heparina-seTEG than in Rapid TEG. These differences were related just to clot formation. The laboratory changes had no impact on clinical judgement. ER -
ČUNDRLE, Ivan, Vladimír ŠRÁMEK, Martin PAVLÍK, Pavel SUK, Iveta RADOUŠKOVÁ a Václav ZVONÍČEK. The influence of temperature adjustment on thromboelastography results: prospectíve cohort study. \textit{Anesteziologie a intenzivní medicína}. 2011, roč.~22, č.~5, s.~253-259. ISSN~1214-2158.
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