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@article{968068, author = {Dvořák, Petr and Novák, Miroslav and Kamarýt, Pavel and Slaná, Bronislava and Lipoldová, Jolana and Dvořák, Pavel}, article_number = {1}, doi = {http://dx.doi.org/10.1093/europace/eur274}, keywords = {Pacemaker electrodes; ICD electrodes; Histology; Steroid-eluting pacing electrodes}, language = {eng}, issn = {1099-5129}, journal = {Europace}, title = {Histological findings around electrodes in pacemaker and implantable cardioverterdefibrillator patients: comparison of steroideluting and non-steroid-eluting electrodes}, volume = {14}, year = {2012} }
TY - JOUR ID - 968068 AU - Dvořák, Petr - Novák, Miroslav - Kamarýt, Pavel - Slaná, Bronislava - Lipoldová, Jolana - Dvořák, Pavel PY - 2012 TI - Histological findings around electrodes in pacemaker and implantable cardioverterdefibrillator patients: comparison of steroideluting and non-steroid-eluting electrodes JF - Europace VL - 14 IS - 1 SP - 117-123 EP - 117-123 SN - 10995129 KW - Pacemaker electrodes KW - ICD electrodes KW - Histology KW - Steroid-eluting pacing electrodes N2 - The aim was to analyse histological findings surrounding the electrodes in pacemaker/implantable cardioverter-defibrillator (PM/ ICD) patients and to compare histology around steroid-eluting and non-steroid ventricular pacing electrodes. In autopsied PM/ICD patients histopathological findings around the electrodes were determined. Seventy patients were studied, PM(58), ICD(12), mean age 75.1+9.3 years. The implantation2death interval was 4.0+3.3 years. Most causes of death were cardiac (PM 52%, ICD 58%). The majority of atrial electrodes were attached to the endocardium and most ventricular electrodes were found in the myocardium. The maximum thickness of the fibrous electrode sheath was greatest for the ICD ventricular electrodes. Some electrodes were covered with fibrin thrombi and granulation tissue, most frequently in the ICD ventricular electrodes. The fibrous sheath usually contained chronic inflammatory cells and in some cases particles of foreign material, foreign body giant cells, and haematogenous pigment. The tissue around steroid-eluting ventricle PM electrodes was compared with the tissue around the non-steroid-eluting ventricle PM electrodes; granulation tissue, foreign material, giant cells being found more frequently around the steroid-eluting electrodes. The fibrous sheath was slightly thinner in the steroideluting electrodes. The histology around four coronary sinus electrodes was described. Atrial electrodes were attached more superficially to the endocardium while PM and ICD ventricular electrodes were more frequently embedded in the myocardium. The electrodes were covered by a connective tissue sheath as a result of thrombus organization. This process persisted most frequently around ICD ventricular electrodes. Only borderline differences were found between the histological findings around steroid-eluting and non-steroideluting PM ventricular electrodes. ER -
DVOŘÁK, Petr, Miroslav NOVÁK, Pavel KAMARÝT, Bronislava SLANÁ, Jolana LIPOLDOVÁ a Pavel DVOŘÁK. Histological findings around electrodes in pacemaker and implantable cardioverterdefibrillator patients: comparison of steroideluting and non-steroid-eluting electrodes. \textit{Europace}. 2012, roč.~14, č.~1, s.~117-123. ISSN~1099-5129. Dostupné z: https://dx.doi.org/10.1093/europace/eur274.
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