ŠÁNA, Jiří, Marian HAJDÚCH, Jaroslav MICHÁLEK, Rostislav VYZULA and Ondřej SLABÝ. MicroRNAs and glioblastoma: roles in core signalling pathways and potential clinical implications. Journal of Cellular and Molecular Medicine. 2011, vol. 15, No 8, p. 1636-1644. ISSN 1582-1838. Available from: https://dx.doi.org/10.1111/j.1582-4934.2011.01317.x.
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Basic information
Original name MicroRNAs and glioblastoma: roles in core signalling pathways and potential clinical implications
Authors ŠÁNA, Jiří (203 Czech Republic, guarantor, belonging to the institution), Marian HAJDÚCH (203 Czech Republic), Jaroslav MICHÁLEK (203 Czech Republic, belonging to the institution), Rostislav VYZULA (203 Czech Republic, belonging to the institution) and Ondřej SLABÝ (203 Czech Republic, belonging to the institution).
Edition Journal of Cellular and Molecular Medicine, 2011, 1582-1838.
Other information
Original language English
Type of outcome Article in a journal
Field of Study Genetics and molecular biology
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 4.125
RIV identification code RIV/00216224:14110/11:00055225
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1111/j.1582-4934.2011.01317.x
UT WoS 000292700800002
Keywords in English glioblastoma; microRNAs; prognosis; prediction; therapeutic targets
Tags International impact
Changed by Changed by: Ing. Mgr. Věra Pospíšilíková, učo 9005. Changed: 31/7/2013 14:12.
Abstract
MicroRNAs (miRNAs) are endogenously expressed small non-coding RNAs that act as post-transcriptional regulators of gene expression. Dysregulation of these molecules has been indicated in the development of many cancers. Altered expression levels of several miRNAs were identified also in glioblastoma. It was repeatedly found that miRNAs are involved in important signalling pathways, which play roles in crucial cellular processes, such as proliferation, apoptosis, cell cycle regulation, invasion, angiogenesis and stem cell behaviour. Therefore, miRNAs represent promising therapeutic targets in glioblastoma. In this review, we summarize the current knowledge about miRNAs significance in glioblastoma, with special focus on their involvement in core signalling pathways, their roles in drug resistance and potential clinical implications.
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