| ŽUREK, Jiří a Michal FEDORA. Dynamics of Glial Fibrillary Acidic Protein During Traumatic Brain Injury in Children. The Journal of Trauma: Injury, Infection and Critical Care. Lippincott Williams & Wilkins, 2011, roč. 71, č. 4, s. 854-859. ISSN 0022-5282. Dostupné z: https://dx.doi.org/10.1097/TA.0b013e3182140c8c. |
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@article{969074,
author = {Žurek, Jiří and Fedora, Michal},
article_number = {4},
doi = {http://dx.doi.org/10.1097/TA.0b013e3182140c8c},
keywords = {Glial fibrillary acidic protein; brain injury; outcome; children},
language = {eng},
issn = {0022-5282},
journal = {The Journal of Trauma: Injury, Infection and Critical Care},
title = {Dynamics of Glial Fibrillary Acidic Protein During Traumatic Brain Injury in Children},
volume = {71},
year = {2011}
}
TY - JOUR
ID - 969074
AU - Žurek, Jiří - Fedora, Michal
PY - 2011
TI - Dynamics of Glial Fibrillary Acidic Protein During Traumatic Brain Injury in Children
JF - The Journal of Trauma: Injury, Infection and Critical Care
VL - 71
IS - 4
SP - 854-859
EP - 854-859
PB - Lippincott Williams & Wilkins
SN - 00225282
KW - Glial fibrillary acidic protein
KW - brain injury
KW - outcome
KW - children
N2 - Backgrounds: Glial fibrillary acidic protein (GFAP) is a monomeric intermediate filament protein found in the astroglial cytoskeleton and is not found outside the central nervous system. It is a brain-specific protein that is released after traumatic brain injury (TBI). Methods: This prospective study enrolled 59 children who had TBI, as verified by computed tomography. Daily GFAP measurement began at admission (< 12 hours after trauma) and continued for 6 days. Blood samples were analyzed for GFAP by enzyme-linked immunosorbent assay. Outcome was assessed using the Glasgow Outcome Scale (GOS) at 6 months after injury. Results: The median serum levels of GFAP at admission were 7.47 ng/mL in patients who died, compared with 0.12 ng/mL in patients who survived (p = 0.002). GFAP levels were significantly higher in patients who had a poor outcome 6 months after injury than in those who were alive or had good outcome (p < 0.001). The area under the receiver operating characteristic curve for GFAP was 0.833 for day 0 and 0.884 for day 2. Conclusions: These results suggest that determination of serum levels of GFAP may add to the clinical assessment of the primary damage and prediction of outcome after severe TBI.
ER -
ŽUREK, Jiří a Michal FEDORA. Dynamics of Glial Fibrillary Acidic Protein During Traumatic Brain Injury in Children. \textit{The Journal of Trauma: Injury, Infection and Critical Care}. Lippincott Williams \&{} Wilkins, 2011, roč.~71, č.~4, s.~854-859. ISSN~0022-5282. Dostupné z: https://dx.doi.org/10.1097/TA.0b013e3182140c8c.
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