| CHEN, D., J. D. MCKAY, Gary CLIFFORD, Valerie GABORIEAU, Amelie CHABRIER, Tim WATERBOER, David ZARIDZE, Jolanta LISSOWSKA, Peter RUDNAI, Eleonora FABIANOVA, Vladimir BENCKO, Vladimir JANOUT, Lenka FORETOVÁ, Ioan Nicolae MATES, Neonila SZESZENIA-DABROWSKA, Maria Paula CURADO, Sergio KOIFMAN, Ana MENEZES, Victor WUENSCH-FILHO, Jose ELUF-NETO, Leticia Fernandez GARROTE, Elena MATOS, Diana ZELENIKA, Anne BOLAND, Paolo BOFFETTA, Michael PAWLITA, Mark LATHROP and Paul BRENNAN. Genome-wide association study of HPV seropositivity. Human molecular genetics. England: Oxford University Press, 2011, vol. 20, No 23, p. 4714-4723. ISSN 0964-6906. Available from: https://dx.doi.org/10.1093/hmg/ddr383. |
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@article{969156,
author = {Chen, D. and McKay, J. D. and Clifford, Gary and Gaborieau, Valerie and Chabrier, Amelie and Waterboer, Tim and Zaridze, David and Lissowska, Jolanta and Rudnai, Peter and Fabianova, Eleonora and Bencko, Vladimir and Janout, Vladimir and Foretová, Lenka and Mates, Ioan Nicolae and SzeszeniaandDabrowska, Neonila and Curado, Maria Paula and Koifman, Sergio and Menezes, Ana and WuenschandFilho, Victor and ElufandNeto, Jose and Garrote, Leticia Fernandez and Matos, Elena and Zelenika, Diana and Boland, Anne and Boffetta, Paolo and Pawlita, Michael and Lathrop, Mark and Brennan, Paul},
article_location = {England},
article_number = {23},
doi = {http://dx.doi.org/10.1093/hmg/ddr383},
keywords = {HUMAN-PAPILLOMAVIRUS TYPES; NONMELANOMA SKIN-CANCER; DISEASE ASSOCIATION; CERVICAL-CANCER; EPIDERMODYSPLASIA-VERRUCIFORMIS; UNIVERSITY-STUDENTS; HLA POLYMORPHISMS; IMMUNE-RESPONSES; HUMAN MHC; INFECTION},
language = {eng},
issn = {0964-6906},
journal = {Human molecular genetics},
title = {Genome-wide association study of HPV seropositivity},
volume = {20},
year = {2011}
}
TY - JOUR
ID - 969156
AU - Chen, D. - McKay, J. D. - Clifford, Gary - Gaborieau, Valerie - Chabrier, Amelie - Waterboer, Tim - Zaridze, David - Lissowska, Jolanta - Rudnai, Peter - Fabianova, Eleonora - Bencko, Vladimir - Janout, Vladimir - Foretová, Lenka - Mates, Ioan Nicolae - Szeszenia-Dabrowska, Neonila - Curado, Maria Paula - Koifman, Sergio - Menezes, Ana - Wuensch-Filho, Victor - Eluf-Neto, Jose - Garrote, Leticia Fernandez - Matos, Elena - Zelenika, Diana - Boland, Anne - Boffetta, Paolo - Pawlita, Michael - Lathrop, Mark - Brennan, Paul
PY - 2011
TI - Genome-wide association study of HPV seropositivity
JF - Human molecular genetics
VL - 20
IS - 23
SP - 4714-4723
EP - 4714-4723
PB - Oxford University Press
SN - 09646906
KW - HUMAN-PAPILLOMAVIRUS TYPES
KW - NONMELANOMA SKIN-CANCER
KW - DISEASE ASSOCIATION
KW - CERVICAL-CANCER
KW - EPIDERMODYSPLASIA-VERRUCIFORMIS
KW - UNIVERSITY-STUDENTS
KW - HLA POLYMORPHISMS
KW - IMMUNE-RESPONSES
KW - HUMAN MHC
KW - INFECTION
N2 - High-risk alpha mucosal types of human papillomavirus (HPV) cause anogenital and oropharyngeal cancers, whereas beta cutaneous HPV types (e.g. HPV8) have been implicated in non-melanoma skin cancer. Although antibodies against the capsid protein L1 of HPV are considered as markers of cumulative exposure, not all infected persons seroconvert. To identify common genetic variants that influence HPV seroconversion, we performed a two-stage genome-wide association study. Genome-wide genotyping of 316 015 single nucleotide polymorphisms was carried out using the Illumina HumanHap300 BeadChip in 4811 subjects from a central European case-control study of lung, head and neck and kidney cancer that had serology data available on 13 HPV types. Only one association met genome-wide significance criteria, namely that between HPV8 seropositivity and rs9357152 [odds ratio (OR) = 1.37, 95% confidence interval (CI) = 1.24-1.50 for the minor allele G; P = 1.2 x 10(-10)], a common genetic variant (minor allele frequency = 0.33) located within the major histocompatibility complex (MHC) II region at 6p21.32. This association was subsequently replicated in an independent set of 2344 subjects from a Latin American case-control study of head and neck cancer (OR = 1.35, 95% CI = 1.18-1.56, P = 2.2 x 10(-5)), yielding P = 1.3 x 10(-14) in the combined analysis (P-heterogeneity = 0.87). No heterogeneity was noted by cancer status (controls/lung cancer cases/head and neck cancer cases/kidney cancer cases). This study provides a proof of principle that genetic variation plays a role in antibody reactivity to HPV infection.
ER -
CHEN, D., J. D. MCKAY, Gary CLIFFORD, Valerie GABORIEAU, Amelie CHABRIER, Tim WATERBOER, David ZARIDZE, Jolanta LISSOWSKA, Peter RUDNAI, Eleonora FABIANOVA, Vladimir BENCKO, Vladimir JANOUT, Lenka FORETOVÁ, Ioan Nicolae MATES, Neonila SZESZENIA-DABROWSKA, Maria Paula CURADO, Sergio KOIFMAN, Ana MENEZES, Victor WUENSCH-FILHO, Jose ELUF-NETO, Leticia Fernandez GARROTE, Elena MATOS, Diana ZELENIKA, Anne BOLAND, Paolo BOFFETTA, Michael PAWLITA, Mark LATHROP and Paul BRENNAN. Genome-wide association study of HPV seropositivity. \textit{Human molecular genetics}. England: Oxford University Press, 2011, vol.~20, No~23, p.~4714-4723. ISSN~0964-6906. Available from: https://dx.doi.org/10.1093/hmg/ddr383.
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