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@article{969162, author = {Butterbach, K. and Beckmann, L. and de Sanjose, Silvia and Benavente, Yolanda and Becker, Nikolaus and Foretová, Lenka and Maynadie, Marc and Cocco, Pierluigi and Staines, Anthony and Boffetta, Paolo and Brennan, Paul and Nieters, Alexandra}, article_location = {England}, article_number = {3}, doi = {http://dx.doi.org/10.1111/j.1365-2141.2011.08632.x}, keywords = {lymphoma; susceptibility; janus kinase-signal transducer and activator of transcription; epidemiology; association study}, language = {eng}, issn = {0007-1048}, journal = {British Journal of Haematology}, title = {Association of JAK-STAT pathway related genes with lymphoma risk: results of a European case-control study (EpiLymph)}, volume = {153}, year = {2011} }
TY - JOUR ID - 969162 AU - Butterbach, K. - Beckmann, L. - de Sanjose, Silvia - Benavente, Yolanda - Becker, Nikolaus - Foretová, Lenka - Maynadie, Marc - Cocco, Pierluigi - Staines, Anthony - Boffetta, Paolo - Brennan, Paul - Nieters, Alexandra PY - 2011 TI - Association of JAK-STAT pathway related genes with lymphoma risk: results of a European case-control study (EpiLymph) JF - British Journal of Haematology VL - 153 IS - 3 SP - 318-333 EP - 318-333 PB - Wiley-Blackwell SN - 00071048 KW - lymphoma KW - susceptibility KW - janus kinase-signal transducer and activator of transcription KW - epidemiology KW - association study N2 - Previous studies have suggested an important role for the Janus kinase-signal transducer and activator of transcription (JAK-STAT) signalling pathway in tumour development. Therefore, we explored genetic variants in JAK-STAT pathway associated genes with lymphoma risk. In samples of the EpiLymph case-control study we genotyped 1536 single nucleotide polymorphisms (SNPs) using GoldenGate BeadArray (TM) Technology (Illumina, San Diego, CA, USA). Here, we report the associations between selected SNPs and haplotypes of the JAK-STAT pathway and risk of Hodgkin lymphoma (HL), B-cell non-Hodgkin lymphoma (B-NHL) and most frequent B-NHL subtypes. Among 210 relevant JAK-STAT pathway-related SNPs, polymorphisms in nine genes (BMF, IFNG, IL12A, SOCS1, STAT1, STAT3, STAT5A, STAT6, TP63) were significantly associated with lymphoma risk. At a study-wise significance level, we obtained a risk reduction of 28% among carriers of the heterozygous genotype of the STAT3 variant (rs1053023) for B-NHL. For six other variants within the STAT3 gene we observed an inverse association with different lymphoma subtypes. A reduced risk for HL was observed for the heterozygous genotype of the STAT6 SNP (rs324011). This is an explorative investigation to examine associations between JAK-STAT signalling related genes and lymphoma risk. The results implicate a relevant role of certain pathway-related genes in lymphomagenesis, but still need to be approved by independent studies. ER -
BUTTERBACH, K., L. BECKMANN, Silvia DE SANJOSE, Yolanda BENAVENTE, Nikolaus BECKER, Lenka FORETOVÁ, Marc MAYNADIE, Pierluigi COCCO, Anthony STAINES, Paolo BOFFETTA, Paul BRENNAN a Alexandra NIETERS. Association of JAK-STAT pathway related genes with lymphoma risk: results of a European case-control study (EpiLymph). \textit{British Journal of Haematology}. England: Wiley-Blackwell, 2011, roč.~153, č.~3, s.~318-333. ISSN~0007-1048. Dostupné z: https://dx.doi.org/10.1111/j.1365-2141.2011.08632.x.
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