| CASABONNE, D., O. REINA, Yolanda BENAVENTE, Nikolaus BECKER, Marc MAYNADIE, Lenka FORETOVÁ, Pierluigi COCCO, Anna GONZALEZ-NEIRA, Alexandra NIETERS, Paolo BOFFETTA, Jaap M. MIDDELDORP and Silvia DE SANJOSE. Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph. Haematologica. Italy: Ferrata Storti Foundation, 2011, vol. 96, No 2, p. 323-327. ISSN 0390-6078. Available from: https://dx.doi.org/10.3324/haematol.2010.031161. |
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@article{969170,
author = {Casabonne, D. and Reina, O. and Benavente, Yolanda and Becker, Nikolaus and Maynadie, Marc and Foretová, Lenka and Cocco, Pierluigi and GonzalezandNeira, Anna and Nieters, Alexandra and Boffetta, Paolo and Middeldorp, Jaap M. and de Sanjose, Silvia},
article_location = {Italy},
article_number = {2},
doi = {http://dx.doi.org/10.3324/haematol.2010.031161},
keywords = {chronic lymphocytic leukemia; epidemiology; Epstein Barr virus; interaction; polymorphism},
language = {eng},
issn = {0390-6078},
journal = {Haematologica},
title = {Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph},
volume = {96},
year = {2011}
}
TY - JOUR
ID - 969170
AU - Casabonne, D. - Reina, O. - Benavente, Yolanda - Becker, Nikolaus - Maynadie, Marc - Foretová, Lenka - Cocco, Pierluigi - Gonzalez-Neira, Anna - Nieters, Alexandra - Boffetta, Paolo - Middeldorp, Jaap M. - de Sanjose, Silvia
PY - 2011
TI - Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph
JF - Haematologica
VL - 96
IS - 2
SP - 323-327
EP - 323-327
PB - Ferrata Storti Foundation
SN - 03906078
KW - chronic lymphocytic leukemia
KW - epidemiology
KW - Epstein Barr virus
KW - interaction
KW - polymorphism
N2 - Using EpiLymph case-control data, we found that chronic lymphocytic leukemia patients were more likely to have abnormal reactive serological patterns to Epstein Barr virus than controls. Here, we aimed to assess whether this association is modified by genetic variants. We examined 1,305 Single Nucleotide Polymorphisms from 300 selected genes related to various pathways in 240 cases and 513 controls from five European centers. In a recessive model, patients positive to aberrant antibody pattern and homozygous for rare genotypes in rs8113877T > G or rs17576A > G of the MMP9 gene were at highest risk of chronic lymphocytic leukemia. In a dominant model, TP73 showed the highest risk in patients positive to aberrant antibody pattern and homozygous for the wild-type genotype in rs1885859G > C or rs3765701A > T. All interactions were additive and no main effect was observed. The strong interactions observed may be indicative of a specific pathway in cancer genesis. Confirmation of these results is warranted.
ER -
CASABONNE, D., O. REINA, Yolanda BENAVENTE, Nikolaus BECKER, Marc MAYNADIE, Lenka FORETOVÁ, Pierluigi COCCO, Anna GONZALEZ-NEIRA, Alexandra NIETERS, Paolo BOFFETTA, Jaap M. MIDDELDORP and Silvia DE SANJOSE. Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph. \textit{Haematologica}. Italy: Ferrata Storti Foundation, 2011, vol.~96, No~2, p.~323-327. ISSN~0390-6078. Available from: https://dx.doi.org/10.3324/haematol.2010.031161.
|
