| STARÝ, J., V. MIHÁL, P. SMÍŠEK, B. BLAŽEK, Y. JABALI, Hana HRSTKOVÁ, J. HAK, D. PROCHÁZKOVÁ, Z. ČERNÁ, Jaroslav ŠTĚRBA, J. TRKA, O. HRUŠÁK, J. ZUNA, E. MEJSTŘÍKOVÁ, I. JANOTOVÁ, P. SEDLÁČEK, H. PTOSZKOVÁ, D. POSPÍŠILOVÁ, K. TOUŠOVSKÁ, P. TIMR, V. VÁVRA, K. ZDRÁHALOVÁ, L. ŠRÁMKOVÁ, Z. ZEMANOVÁ, M. JAROŠOVÁ, P. GAJDOŠ a O. HRODEK. History of treatment and long-term outcome in children with acute lymphoblastic leukemia in the Czech Republic. memo - Magazine of European Medical Oncology. Springer, 2011, roč. 4, č. 3, s. 196-201. ISSN 1865-5041. Dostupné z: https://dx.doi.org/10.1007/s12254-011-0289-9. |
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@article{969521,
author = {Starý, J. and Mihál, V. and Smíšek, P. and Blažek, B. and Jabali, Y. and Hrstková, Hana and Hak, J. and Procházková, D. and Černá, Z. and Štěrba, Jaroslav and Trka, J. and Hrušák, O. and Zuna, J. and Mejstříková, E. and Janotová, I. and Sedláček, P. and Ptoszková, H. and Pospíšilová, D. and Toušovská, K. and Timr, P. and Vávra, V. and Zdráhalová, K. and Šrámková, L. and Zemanová, Z. and Jarošová, M. and Gajdoš, P. and Hrodek, O.},
article_number = {3},
doi = {http://dx.doi.org/10.1007/s12254-011-0289-9},
keywords = {Acute lymphoblastic leukaemia; children; treatment; diagnostics},
language = {eng},
issn = {1865-5041},
journal = {memo - Magazine of European Medical Oncology},
title = {History of treatment and long-term outcome in children with acute lymphoblastic leukemia in the Czech Republic},
url = {http://www.springerlink.com/content/107311rn7g161jmt/fulltext.pdf},
volume = {4},
year = {2011}
}
TY - JOUR
ID - 969521
AU - Starý, J. - Mihál, V. - Smíšek, P. - Blažek, B. - Jabali, Y. - Hrstková, Hana - Hak, J. - Procházková, D. - Černá, Z. - Štěrba, Jaroslav - Trka, J. - Hrušák, O. - Zuna, J. - Mejstříková, E. - Janotová, I. - Sedláček, P. - Ptoszková, H. - Pospíšilová, D. - Toušovská, K. - Timr, P. - Vávra, V. - Zdráhalová, K. - Šrámková, L. - Zemanová, Z. - Jarošová, M. - Gajdoš, P. - Hrodek, O.
PY - 2011
TI - History of treatment and long-term outcome in children with acute lymphoblastic leukemia in the Czech Republic
JF - memo - Magazine of European Medical Oncology
VL - 4
IS - 3
SP - 196-201
EP - 196-201
PB - Springer
SN - 18655041
KW - Acute lymphoblastic leukaemia
KW - children
KW - treatment
KW - diagnostics
UR - http://www.springerlink.com/content/107311rn7g161jmt/fulltext.pdf
N2 - Treatment of childhood acute lymphoblastic leukemia (ALL) was unifi ed in the year 1986 in the Czech Republic using BFM protocols. Patients and methods: Children were treated in 10 and later on in 8 centers localized at the pediatric departments of the biggest hospitals. More than 1.000 children and adolescents up to the age of 18 years were treated between 1986 and 2002 on three consecutive studies ALL-BFM 83, ALL-BFM 90 and ALL-BFM 95. Results: Event-free survival and overall survival improved gradually from 58/62% on ALL-BFM 83 through 70.5/76.6% on ALL-BFM 90 until 72.1/80.2% on ALL-BFM 95. At the same time the incidence of toxic deaths was decreasing and the success in the achievement of complete remission was increasing. Diagnostics in the Czech Republic improved remarkably in the 1990 with gradual introduction of centralized fl ow cytometry and molecular genetic analysis in one reference laboratory (CLIP = Childhood Leukemia Investigation Prague), which since then has become an internationally respected research center. Conclusions: Building up a network of closely collaborating leukemia centers covering the whole country, together with the establishment of reference and research laboratories has paved the way for the implementation of the Czech Pediatric Hematology Working Group (CPH) into the international studies Interfant 99, EsPhALL and for the active role in ALL IC-BFM 2002, the I-BFM-SG international randomized trial for treatment of children and adolescents with non-B ALL starting in 2002.
ER -
STARÝ, J., V. MIHÁL, P. SMÍŠEK, B. BLAŽEK, Y. JABALI, Hana HRSTKOVÁ, J. HAK, D. PROCHÁZKOVÁ, Z. ČERNÁ, Jaroslav ŠTĚRBA, J. TRKA, O. HRUŠÁK, J. ZUNA, E. MEJSTŘÍKOVÁ, I. JANOTOVÁ, P. SEDLÁČEK, H. PTOSZKOVÁ, D. POSPÍŠILOVÁ, K. TOUŠOVSKÁ, P. TIMR, V. VÁVRA, K. ZDRÁHALOVÁ, L. ŠRÁMKOVÁ, Z. ZEMANOVÁ, M. JAROŠOVÁ, P. GAJDOŠ a O. HRODEK. History of treatment and long-term outcome in children with acute lymphoblastic leukemia in the Czech Republic. \textit{memo - Magazine of European Medical Oncology}. Springer, 2011, roč.~4, č.~3, s.~196-201. ISSN~1865-5041. Dostupné z: https://dx.doi.org/10.1007/s12254-011-0289-9.
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