Clinical Relevance of uPA, uPAR, PAI 1 and PAI 2 Tissue
Expression and Plasma PAI 1 Level in Colorectal Carcinoma
Patients

J 2011

Clinical Relevance of uPA, uPAR, PAI 1 and PAI 2 Tissue Expression and Plasma PAI 1 Level in Colorectal Carcinoma Patients

HALÁMKOVÁ, Jana, Igor KISS, Zdeněk PAVLOVSKÝ, Jiří JARKOVSKÝ, Jiří TOMÁŠEK et. al.

Základní údaje

Originální název

Clinical Relevance of uPA, uPAR, PAI 1 and PAI 2 Tissue Expression and Plasma PAI 1 Level in Colorectal Carcinoma Patients

Autoři

HALÁMKOVÁ, Jana (203 Česká republika, garant, domácí), Igor KISS (203 Česká republika, domácí), Zdeněk PAVLOVSKÝ (203 Česká republika, domácí), Jiří JARKOVSKÝ (203 Česká republika, domácí), Jiří TOMÁŠEK (203 Česká republika, domácí), Štěpán TUČEK (203 Česká republika, domácí), Lada HANAKOVA (203 Česká republika), Mojmír MOULIS (203 Česká republika, domácí), Zbyněk ČECH (203 Česká republika, domácí), Jiřina ZAVŘELOVÁ (203 Česká republika, domácí) a Miroslav PENKA (203 Česká republika, domácí)

Vydání

Hepatogastroenterology, 2011, 0172-6390

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Německo

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 0.658

Kód RIV

RIV/00216224:14110/11:00055477

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.5754/hge10232

UT WoS

000300532700015

Klíčová slova anglicky

Colorectal cancer; Plasminogen activator system; PAI 1; PAI 2; uPA; uPAR

Příznaky

Mezinárodní význam

Změněno: 9. 2. 2012 07:35, Mgr. Michal Petr

Anotace

V originále

Urokinase (uPA) is a serine protease, which together with uPAR, tPA, PAI 1 and PAI 2 forms the plasminogen activator system, a component of metastatic cascade contributing to the invasive growth and angiogenesis of malignant tumours. Methodology: Both preceding therapy and after 6-8 weeks of the treatment, plasma PAI 1 levels (photometric microplate method on the ELISA) and uPA, uPAR, PAI 1 and PAI 2 tissue expression (immunohistochemical reaction) were analysed from 80 colorectal carcinoma patients. Results: Analysis showed higher pre-treatment plasma levels of PAI 1 in patients with advanced tumours, which decreased after surgery or the start of therapy (p=0.004); Patients with higher plasma level PAI 1 before (0.013) and after therapy (0.004) had significantly shorter survival. There was a higher expression of uPA (p<0.001), uPAR (p<0.001), PAI 1 (p=0.042) and PAI 2 (p<0.001) in advanced colorectal carcinoma. A relationship between PAI 2 (p=0.010) and uPAR (p=0.019) expression and survival was demonstrated. There is a correlation between pre-treatment plasma PAI 1 levels and PAI 2 (p=0.028) and uPAR (p=0.043) expression. Conclusions: Immunohistochemical analysis of PAS in tumour tissue and plasma PAI 1 levels was found to be a useful prognostic factor in colorectal carcinoma patients. Plasma PAI 1 could be advantageous in evaluating the effectiveness of a mode of treatment.

Citovat

HALÁMKOVÁ, Jana, Igor KISS, Zdeněk PAVLOVSKÝ, Jiří JARKOVSKÝ, Jiří TOMÁŠEK, Štěpán TUČEK, Lada HANAKOVA, Mojmír MOULIS, Zbyněk ČECH, Jiřina ZAVŘELOVÁ a Miroslav PENKA. Clinical Relevance of uPA, uPAR, PAI 1 and PAI 2 Tissue Expression and Plasma PAI 1 Level in Colorectal Carcinoma Patients. Hepatogastroenterology. 2011, roč. 58, č. 112, s. 1918-1925. ISSN 0172-6390. Dostupné z: https://dx.doi.org/10.5754/hge10232.

@article{970398,
   author = {Halámková, Jana and Kiss, Igor and Pavlovský, Zdeněk and Jarkovský, Jiří and Tomášek, Jiří and Tuček, Štěpán and Hanakova, Lada and Moulis, Mojmír and Čech, Zbyněk and Zavřelová, Jiřina and Penka, Miroslav},
   article_number = {112},
   doi = {http://dx.doi.org/10.5754/hge10232},
   keywords = {Colorectal cancer; Plasminogen activator system; PAI 1; PAI 2; uPA; uPAR},
   language = {eng},
   issn = {0172-6390},
   journal = {Hepatogastroenterology},
   title = {Clinical Relevance of uPA, uPAR, PAI 1 and PAI 2 Tissue Expression and Plasma PAI 1 Level in Colorectal Carcinoma Patients},
   volume = {58},
   year = {2011}
}

TY  - JOUR
ID  - 970398
AU  - Halámková, Jana - Kiss, Igor - Pavlovský, Zdeněk - Jarkovský, Jiří - Tomášek, Jiří - Tuček, Štěpán - Hanakova, Lada - Moulis, Mojmír - Čech, Zbyněk - Zavřelová, Jiřina - Penka, Miroslav
PY  - 2011
TI  - Clinical Relevance of uPA, uPAR, PAI 1 and PAI 2 Tissue Expression and Plasma PAI 1 Level in Colorectal Carcinoma Patients
JF  - Hepatogastroenterology
VL  - 58
IS  - 112
SP  - 1918-1925
EP  - 1918-1925
SN  - 01726390
KW  - Colorectal cancer
KW  - Plasminogen activator system
KW  - PAI 1
KW  - PAI 2
KW  - uPA
KW  - uPAR
N2  - Urokinase (uPA) is a serine protease, which together with uPAR, tPA, PAI 1 and PAI 2 forms the plasminogen activator system, a component of metastatic cascade contributing to the invasive growth and angiogenesis of malignant tumours. Methodology: Both preceding therapy and after 6-8 weeks of the treatment, plasma PAI 1 levels (photometric microplate method on the ELISA) and uPA, uPAR, PAI 1 and PAI 2 tissue expression (immunohistochemical reaction) were analysed from 80 colorectal carcinoma patients. Results: Analysis showed higher pre-treatment plasma levels of PAI 1 in patients with advanced tumours, which decreased after surgery or the start of therapy (p=0.004); Patients with higher plasma level PAI 1 before (0.013) and after therapy (0.004) had significantly shorter survival. There was a higher expression of uPA (p<0.001), uPAR (p<0.001), PAI 1 (p=0.042) and PAI 2 (p<0.001) in advanced colorectal carcinoma. A relationship between PAI 2 (p=0.010) and uPAR (p=0.019) expression and survival was demonstrated. There is a correlation between pre-treatment plasma PAI 1 levels and PAI 2 (p=0.028) and uPAR (p=0.043) expression. Conclusions: Immunohistochemical analysis of PAS in tumour tissue and plasma PAI 1 levels was found to be a useful prognostic factor in colorectal carcinoma patients. Plasma PAI 1 could be advantageous in evaluating the effectiveness of a mode of treatment.
ER  -

HALÁMKOVÁ, Jana, Igor KISS, Zdeněk PAVLOVSKÝ, Jiří JARKOVSKÝ, Jiří TOMÁŠEK, Štěpán TUČEK, Lada HANAKOVA, Mojmír MOULIS, Zbyněk ČECH, Jiřina ZAVŘELOVÁ a Miroslav PENKA. Clinical Relevance of uPA, uPAR, PAI 1 and PAI 2 Tissue Expression and Plasma PAI 1 Level in Colorectal Carcinoma Patients. \textit{Hepatogastroenterology}. 2011, roč.~58, č.~112, s.~1918-1925. ISSN~0172-6390. Dostupné z: https://dx.doi.org/10.5754/hge10232.

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