Involvement of the subthalamic nucleus and globus pallidus internus in attention

BOČKOVÁ, Martina, Jan CHLÁDEK, P. JURÁK, J. HALÁMEK, Marek BALÁŽ and Ivan REKTOR. Involvement of the subthalamic nucleus and globus pallidus internus in attention. JOURNAL OF NEURAL TRANSMISSION. 2011, vol. 118, No 8, p. 1235–1245. ISSN 0300-9564. Available from: https://dx.doi.org/10.1007/s00702-010-0575-4.

Basic information

• Original name: Involvement of the subthalamic nucleus and globus pallidus internus in attention
• Authors: BOČKOVÁ, Martina (203 Czech Republic, guarantor, belonging to the institution), Jan CHLÁDEK (203 Czech Republic), P. JURÁK (203 Czech Republic), J. HALÁMEK (203 Czech Republic), Marek BALÁŽ (703 Slovakia, belonging to the institution) and Ivan REKTOR (203 Czech Republic, belonging to the institution).
• Edition: JOURNAL OF NEURAL TRANSMISSION, 2011, 0300-9564.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30000 3. Medical and Health Sciences
• Country of publisher: Austria
• Confidentiality degree: is not subject to a state or trade secret
• Impact factor: Impact factor: 2.730
• RIV identification code: RIV/00216224:14110/11:00055707
• Organization unit: Faculty of Medicine
• Doi: http://dx.doi.org/10.1007/s00702-010-0575-4
• UT WoS: 000293244800015
• Keywords in English: Basal ganglia; ERP; ERD/S; Attention; DBS
• Tags: International impact

Abstract

We studied the appearance of cognitive event-related potentials (ERPs) and event-related de/synchronizations (ERD/S) in the subthalamic nucleus (STN) and globus pallidus internus (GPi). We particularly focused on the rare non-target (distractor) stimuli processing. ERPs and ERD/S in the alpha and beta frequency range were analyzed in seven Parkinson's disease patients and one primary dystonia patient with implanted deep brain stimulation (DBS) electrodes. A visual three-stimulus protocol was used (frequent stimulus, target stimulus, and distractor). The non-target and distractor-related waveforms manifested similar shapes. A specific positive ERP peak around 200 ms and a low alpha frequency ERS were detected from the STN as a response to the distractor stimuli in six of the patients with Parkinson's disease and also in the primary dystonia patient's GPi. This positivity probably reflects an attentional orienting response to the distractor stimuli. The STN and GPi are probably involved in attentional cerebral networks.

Links

• MSM0021622404, plan (intention): Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.