Staphylococcal scalded skin syndrome in the Czech Republic: an
epidemiological study

J 2012

Staphylococcal scalded skin syndrome in the Czech Republic: an epidemiological study

LIPOVÝ, Břetislav, Pavel BRYCHTA, Zuzana CHALOUPKOVÁ and Ivan SUCHÁNEK

Basic information

Original name

Staphylococcal scalded skin syndrome in the Czech Republic: an epidemiological study

Authors

LIPOVÝ, Břetislav (203 Czech Republic, guarantor, belonging to the institution), Pavel BRYCHTA (203 Czech Republic, belonging to the institution), Zuzana CHALOUPKOVÁ (203 Czech Republic, belonging to the institution) and Ivan SUCHÁNEK (203 Czech Republic)

Edition

Burns, 2012, 0305-4179

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30200 3.2 Clinical medicine

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 1.799

RIV identification code

RIV/00216224:14110/12:00059356

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.burns.2011.08.005

UT WoS

000301621500021

Keywords in English

Staphylococcal scalded skin syndrome; Exfoliative toxin; Desmoglein-1; Epidemiology

Abstract

V originále

Objective To identify the basic epidemiological characteristics of children hospitalized with diagnosis of Staphylococcal scalded skin syndrome in the Czech Republic in the years 1994–2009. Introduction Staphylococcal scalded skin syndrome (SSSS) is a relatively rare disease in childhood. This syndrome was first defined in 1878 by Baron Gottfried Ritter von Rittershainem and belongs to the group of diseases called Burn-like syndromes. It is a bullous skin disease caused by exfoliative toxins which are produced by certain types of Staphyloccocus aureus. Typical structures affected by these toxins are desmosome proteins called Desmoglein-1 located in the stratum granulosum of epidermis. Unlike in Lyell's syndrome or Stevens-Johnson's syndrome, the exfoliation is caused by loss of adhesivity particularly in the stratum granulosum and not by induction of apoptosis in the dermo-epidermal junction. Material and methods This retrospective study was conducted on patients hospitalized in the Czech Republic in the period from 1.1.1994 to 31.12.2009. The basic condition for the inclusion in the retrospective study was age under 1 year and hospitalization due to SSSS. A total of 399 children (177 girls) fulfilled the criteria for inclusion into the study. Information was obtained from a central data depository, the Department of Health Information and Statistics, Czech Republic. Results A total of 399 children under 1 year were hospitalized for the diagnosis of SSSS in the study period. The group included 177 girls and 222 boys. M:F ratio was 1.25:1. The average incidence of SSSS in the Czech Republic was 25.11 cases per 100 000 children under 1 year of age. The highest recorded incidence in the followed period was in 1994, when a total of 57 cases of SSSS was reported, namely 53.47 per 100 000 children. By contrast, in 2003, there were reported only 12 cases and the incidence of 12.81 per 100 000 children. The average length of hospitalization was 6.39 days. In 1995, the highest average length of hospitalization was reported, which was 8.1 days, and then in 2007, the lowest average length of hospitalization, 4.4 days. There was no significant difference in the length of hospitalization in boys and girls. None of the 399 children in the population died. Conclusion In our retrospective study, we established basic epidemiological characteristics of a group of children aged under 1 year with diagnosis of SSSS. As epidemiological data show, the occurrence of this syndrome is not sporadic, but steady.

Citovat

LIPOVÝ, Břetislav, Pavel BRYCHTA, Zuzana CHALOUPKOVÁ and Ivan SUCHÁNEK. Staphylococcal scalded skin syndrome in the Czech Republic: an epidemiological study. Burns. 2012, vol. 38, No 2, p. 296–300. ISSN 0305-4179. Available from: https://dx.doi.org/10.1016/j.burns.2011.08.005.

@article{972419,
   author = {Lipový, Břetislav and Brychta, Pavel and Chaloupková, Zuzana and Suchánek, Ivan},
   article_number = {2},
   doi = {http://dx.doi.org/10.1016/j.burns.2011.08.005},
   keywords = {Staphylococcal scalded skin syndrome; Exfoliative toxin; Desmoglein-1; Epidemiology},
   language = {eng},
   issn = {0305-4179},
   journal = {Burns},
   title = {Staphylococcal scalded skin syndrome in the Czech Republic: an epidemiological study},
   volume = {38},
   year = {2012}
}

TY  - JOUR
ID  - 972419
AU  - Lipový, Břetislav - Brychta, Pavel - Chaloupková, Zuzana - Suchánek, Ivan
PY  - 2012
TI  - Staphylococcal scalded skin syndrome in the Czech Republic: an epidemiological study
JF  - Burns
VL  - 38
IS  - 2
SP  - 296–300
EP  - 296–300
SN  - 03054179
KW  - Staphylococcal scalded skin syndrome
KW  - Exfoliative toxin
KW  - Desmoglein-1
KW  - Epidemiology
N2  - Objective To identify the basic epidemiological characteristics of children hospitalized with diagnosis of Staphylococcal scalded skin syndrome in the Czech Republic in the years 1994–2009. Introduction Staphylococcal scalded skin syndrome (SSSS) is a relatively rare disease in childhood. This syndrome was first defined in 1878 by Baron Gottfried Ritter von Rittershainem and belongs to the group of diseases called Burn-like syndromes. It is a bullous skin disease caused by exfoliative toxins which are produced by certain types of Staphyloccocus aureus. Typical structures affected by these toxins are desmosome proteins called Desmoglein-1 located in the stratum granulosum of epidermis. Unlike in Lyell's syndrome or Stevens-Johnson's syndrome, the exfoliation is caused by loss of adhesivity particularly in the stratum granulosum and not by induction of apoptosis in the dermo-epidermal junction. Material and methods This retrospective study was conducted on patients hospitalized in the Czech Republic in the period from 1.1.1994 to 31.12.2009. The basic condition for the inclusion in the retrospective study was age under 1 year and hospitalization due to SSSS. A total of 399 children (177 girls) fulfilled the criteria for inclusion into the study. Information was obtained from a central data depository, the Department of Health Information and Statistics, Czech Republic. Results A total of 399 children under 1 year were hospitalized for the diagnosis of SSSS in the study period. The group included 177 girls and 222 boys. M:F ratio was 1.25:1. The average incidence of SSSS in the Czech Republic was 25.11 cases per 100 000 children under 1 year of age. The highest recorded incidence in the followed period was in 1994, when a total of 57 cases of SSSS was reported, namely 53.47 per 100 000 children. By contrast, in 2003, there were reported only 12 cases and the incidence of 12.81 per 100 000 children. The average length of hospitalization was 6.39 days. In 1995, the highest average length of hospitalization was reported, which was 8.1 days, and then in 2007, the lowest average length of hospitalization, 4.4 days. There was no significant difference in the length of hospitalization in boys and girls. None of the 399 children in the population died. Conclusion In our retrospective study, we established basic epidemiological characteristics of a group of children aged under 1 year with diagnosis of SSSS. As epidemiological data show, the occurrence of this syndrome is not sporadic, but steady.
ER  -

LIPOVÝ, Břetislav, Pavel BRYCHTA, Zuzana CHALOUPKOVÁ and Ivan SUCHÁNEK. Staphylococcal scalded skin syndrome in the Czech Republic: an epidemiological study. \textit{Burns}. 2012, vol.~38, No~2, p.~296–300. ISSN~0305-4179. Available from: https://dx.doi.org/10.1016/j.burns.2011.08.005.

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