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@article{979765,
author = {Bienertová Vašků, Julie and Bienert, Petr and Forejt, Martin and Tomandl, Josef and Derflerová Brázdová, Zuzana and Vašků, Anna},
article_number = {3},
doi = {http://dx.doi.org/10.1017/S0007114509991887},
keywords = {Adipokines; Polymorphisms; Obesity; Nutrition; Feeding behaviour},
language = {eng},
issn = {0007-1145},
journal = {BRITISH JOURNAL OF NUTRITION},
title = {Genotype X nutrient association of common polymorphisms in obesity-related genes with food preferences and time structure of energy intake},
volume = {103},
year = {2010}
}
TY - JOUR
ID - 979765
AU - Bienertová Vašků, Julie - Bienert, Petr - Forejt, Martin - Tomandl, Josef - Derflerová Brázdová, Zuzana - Vašků, Anna
PY - 2010
TI - Genotype X nutrient association of common polymorphisms in obesity-related genes with food preferences and time structure of energy intake
JF - BRITISH JOURNAL OF NUTRITION
VL - 103
IS - 3
SP - 352-359
EP - 352-359
SN - 00071145
KW - Adipokines
KW - Polymorphisms
KW - Obesity
KW - Nutrition
KW - Feeding behaviour
N2 - Personal food preferences can either enhance or Suppress the development of obesity and the selection and proportion of macronutrients in the diet seem to have a heritable component. In the present study, we therefore focused on dietary composition as a specific trait related to obesity and we determined whether genetic variations in leptin (LEP), LEP receptor (LEPR), adiponectin (ADIPOQ), IL-6 and pro-opiomelanocortin (POMC) underlie specific native food preferences and obesity-related anthropometric parameters. The total of 409 individuals of Czech Caucasian origin were enrolled into the present study and 7 d food records were obtained from the study subjects along with selected anthropometric measurements. In a subset of study subjects, plasma levels of ADIPOQ, LEP and soluble LEPR were measured. Independently of the BMI of the individuals, common variations in LEP and LEPR genes were associated with specific eating patterns, mainly with respect to timing of eating. The LEP + 19A/G polymorphism served as an independent predictor for BMI, percentage of body fat and skinfold thickness and significantly affected the time structure of the daily energy intake. The POMC RsaI polymorphism was associated with percentage of body fat. The ADIPOQ 45 T/G polymorphism was associated with the thickness of the subscapular skinfold. The LEPR Gln223Arg polymorphism was associated with multiple parameters, including diastolic blood pressure, meal sizes during the day and plasma ADIPOQ levels. In a separate analysis, soluble leptin receptor (sObR) plasma levels and LEP:sObR ratio were significantly correlated with systolic blood pressure (beta = -0-66, P=0.002; beta = -1.23, P=0.02) and sObR plasma levels also served as an independent predictor for diastolic blood pressure (beta = - 0.50; P=0-04). To conclude, we report common allelic variants associated with specific feeding behaviour and obesity-related anthropometric traits. Moreover, we identified allelic variants that significantly influence the time structure of food intake during the day.
ER -
BIENERTOVÁ VAŠKŮ, Julie, Petr BIENERT, Martin FOREJT, Josef TOMANDL, Zuzana DERFLEROVÁ BRÁZDOVÁ a Anna VAŠKŮ. Genotype X nutrient association of common polymorphisms in obesity-related genes with food preferences and time structure of energy intake. \textit{BRITISH JOURNAL OF NUTRITION}. 2010, roč.~103, č.~3, s.~352-359. ISSN~0007-1145. Dostupné z: https://dx.doi.org/10.1017/S0007114509991887.
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