JARKOVSKÝ, Jiří, Jiří PAŘENICA, Roman MIKLÍK, Monika PÁVKOVÁ GOLDBERGOVÁ, Petr KALA, Lenka MALÁSKOVÁ, Zdeňka ČERMÁKOVÁ, Martin POLOCZEK, Miroslav VYTISKA, Lenka KUBKOVÁ, Kateřina HELÁNOVÁ, I. PARENICOVA, Simona LITTNEROVÁ, L. DOSTALOVA, P. KUBENA, Anna VAŠKŮ and Jindřich ŠPINAR. Determinants of Invasively Measured Aortic Pulse Pressure and its Relationship with B-type Natriuretic Peptides in Stable Patients with Preserved Left Ventricular Systolic Function. EUROPEAN JOURNAL OF CARDIOVASCULAR MEDICINE. 2012, vol. 11, No 1, p. 32-40. ISSN 2042-4884. doi:10.5083/ejcm.20424884.67.
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Basic information
Original name Determinants of Invasively Measured Aortic Pulse Pressure and its Relationship with B-type Natriuretic Peptides in Stable Patients with Preserved Left Ventricular Systolic Function
Authors JARKOVSKÝ, Jiří (203 Czech Republic, guarantor, belonging to the institution), Jiří PAŘENICA (203 Czech Republic, belonging to the institution), Roman MIKLÍK (203 Czech Republic, belonging to the institution), Monika PÁVKOVÁ GOLDBERGOVÁ (203 Czech Republic, belonging to the institution), Petr KALA (203 Czech Republic, belonging to the institution), Lenka MALÁSKOVÁ (203 Czech Republic), Zdeňka ČERMÁKOVÁ (203 Czech Republic), Martin POLOCZEK (203 Czech Republic, belonging to the institution), Miroslav VYTISKA (703 Slovakia), Lenka KUBKOVÁ (203 Czech Republic, belonging to the institution), Kateřina HELÁNOVÁ (203 Czech Republic, belonging to the institution), I. PARENICOVA (203 Czech Republic), Simona LITTNEROVÁ (203 Czech Republic, belonging to the institution), L. DOSTALOVA (203 Czech Republic), P. KUBENA (203 Czech Republic), Anna VAŠKŮ (203 Czech Republic, belonging to the institution) and Jindřich ŠPINAR (203 Czech Republic, belonging to the institution).
Edition EUROPEAN JOURNAL OF CARDIOVASCULAR MEDICINE, 2012, 2042-4884.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30201 Cardiac and Cardiovascular systems
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
RIV identification code RIV/00216224:14110/12:00059819
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.5083/ejcm.20424884.67
Keywords in English aortic pulse pressure; natriuretic peptides; marker
Changed by Changed by: Ing. Mgr. Věra Pospíšilíková, učo 9005. Changed: 9/4/2013 13:50.
Abstract
Wide aortic pulse pressure (PP) and levels of natriuretic peptides were repeatedly demonstrated as predictors of cardiovascular morbidity and mortality even in a population without a history of heart disease. The aim of the work was to find determinants of invasively measured aortic pulse pressure and B-type natriuretic peptide (BNP), and a relationship of both markers in stable patients undergoing diagnostic coronary angiography with preserved left ventricle systolic function. Population and methods: A total of 386 stable patients with left ventricle ejection fraction > 50%, without acute myocardial infarction, aortic or mitral valve disease were enrolled. Invasive intra-aortic blood pressure was measured using a fluid-filled catheter in the ascending aorta. Samples of venous blood for analysis of the BNP level were drawn before coronary angiography. Results: We found a positive correlation between aortic systolic blood pressure (SBP) and PP (Pearson’s correlation coefficient = 0.44, p<0.001). Positive relationships were determined among aortic PP and gender, age, BNP, glycaemia, high-density lipoprotein (HDL) cholesterol, hypertension and diabetes mellitus. Negative relationships were found among aortic PP and height, weight and ischemic heart disease, but only gender and age were detected as independent factors in multivariate model. Positive correlation of BNP with age, aortic PP, Left ventricular end diastolic pressure (LVEDP), hypertension, smoking and a negative correlation with creatinine, total cholesterol and ischemic heart disease were shown; only age, creatinine, cholesterol and non- smoker status were independent predictors of BNP value in multivariate model. Conclusion: We found independent determinants of two important predictive markers of cardio-vascular morbidity and mortality – BNP and PP - in group of stable patients.
Links
NS10206, research and development projectName: Asociace polymorfismů v genech pro metaloproteinázy, jejich inhibitory, ACE a ACE2 s centrálním pulsním tlakem u kardiovaskulárních pacientů
Investor: Ministry of Health of the CR, Departmental Programme of Research and Development - MH II from 2008 to 2011
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