Determinants of Invasively Measured Aortic Pulse Pressure and
its Relationship with B-type Natriuretic Peptides in Stable
Patients with Preserved Left Ventricular Systolic Function

J 2012

Determinants of Invasively Measured Aortic Pulse Pressure and its Relationship with B-type Natriuretic Peptides in Stable Patients with Preserved Left Ventricular Systolic Function

JARKOVSKÝ, Jiří, Jiří PAŘENICA, Roman MIKLÍK, Monika PÁVKOVÁ GOLDBERGOVÁ, Petr KALA et. al.

Základní údaje

Originální název

Determinants of Invasively Measured Aortic Pulse Pressure and its Relationship with B-type Natriuretic Peptides in Stable Patients with Preserved Left Ventricular Systolic Function

Autoři

JARKOVSKÝ, Jiří (203 Česká republika, garant, domácí), Jiří PAŘENICA (203 Česká republika, domácí), Roman MIKLÍK (203 Česká republika, domácí), Monika PÁVKOVÁ GOLDBERGOVÁ (203 Česká republika, domácí), Petr KALA (203 Česká republika, domácí), Lenka MALÁSKOVÁ (203 Česká republika), Zdeňka ČERMÁKOVÁ (203 Česká republika), Martin POLOCZEK (203 Česká republika, domácí), Miroslav VYTISKA (703 Slovensko), Lenka KUBKOVÁ (203 Česká republika, domácí), Kateřina HELÁNOVÁ (203 Česká republika, domácí), I. PARENICOVA (203 Česká republika), Simona LITTNEROVÁ (203 Česká republika, domácí), L. DOSTALOVA (203 Česká republika), P. KUBENA (203 Česká republika), Anna VAŠKŮ (203 Česká republika, domácí) a Jindřich ŠPINAR (203 Česká republika, domácí)

Vydání

EUROPEAN JOURNAL OF CARDIOVASCULAR MEDICINE, 2012, 2042-4884

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30201 Cardiac and Cardiovascular systems

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Kód RIV

RIV/00216224:14110/12:00059819

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.5083/ejcm.20424884.67

Klíčová slova anglicky

aortic pulse pressure; natriuretic peptides; marker

Změněno: 9. 4. 2013 13:50, Ing. Mgr. Věra Pospíšilíková

Anotace

V originále

Wide aortic pulse pressure (PP) and levels of natriuretic peptides were repeatedly demonstrated as predictors of cardiovascular morbidity and mortality even in a population without a history of heart disease. The aim of the work was to find determinants of invasively measured aortic pulse pressure and B-type natriuretic peptide (BNP), and a relationship of both markers in stable patients undergoing diagnostic coronary angiography with preserved left ventricle systolic function. Population and methods: A total of 386 stable patients with left ventricle ejection fraction > 50%, without acute myocardial infarction, aortic or mitral valve disease were enrolled. Invasive intra-aortic blood pressure was measured using a fluid-filled catheter in the ascending aorta. Samples of venous blood for analysis of the BNP level were drawn before coronary angiography. Results: We found a positive correlation between aortic systolic blood pressure (SBP) and PP (Pearson’s correlation coefficient = 0.44, p<0.001). Positive relationships were determined among aortic PP and gender, age, BNP, glycaemia, high-density lipoprotein (HDL) cholesterol, hypertension and diabetes mellitus. Negative relationships were found among aortic PP and height, weight and ischemic heart disease, but only gender and age were detected as independent factors in multivariate model. Positive correlation of BNP with age, aortic PP, Left ventricular end diastolic pressure (LVEDP), hypertension, smoking and a negative correlation with creatinine, total cholesterol and ischemic heart disease were shown; only age, creatinine, cholesterol and non- smoker status were independent predictors of BNP value in multivariate model. Conclusion: We found independent determinants of two important predictive markers of cardio-vascular morbidity and mortality – BNP and PP - in group of stable patients.

Návaznosti

NS10206, projekt VaV

Název: Asociace polymorfismů v genech pro metaloproteinázy, jejich inhibitory, ACE a ACE2 s centrálním pulsním tlakem u kardiovaskulárních pacientů

Investor: Ministerstvo zdravotnictví ČR, Asociace polymorfismů v genech pro metaloproteinázy, jejich inhibitory, ACE, ACE2 a apelinu s centrálním pulsním tlakem u pacientů s ischemickou chorobou srdeční

Citovat

JARKOVSKÝ, Jiří, Jiří PAŘENICA, Roman MIKLÍK, Monika PÁVKOVÁ GOLDBERGOVÁ, Petr KALA, Lenka MALÁSKOVÁ, Zdeňka ČERMÁKOVÁ, Martin POLOCZEK, Miroslav VYTISKA, Lenka KUBKOVÁ, Kateřina HELÁNOVÁ, I. PARENICOVA, Simona LITTNEROVÁ, L. DOSTALOVA, P. KUBENA, Anna VAŠKŮ a Jindřich ŠPINAR. Determinants of Invasively Measured Aortic Pulse Pressure and its Relationship with B-type Natriuretic Peptides in Stable Patients with Preserved Left Ventricular Systolic Function. EUROPEAN JOURNAL OF CARDIOVASCULAR MEDICINE. 2012, roč. 11, č. 1, s. 32-40. ISSN 2042-4884. Dostupné z: https://dx.doi.org/10.5083/ejcm.20424884.67.

@article{980955,
   author = {Jarkovský, Jiří and Pařenica, Jiří and Miklík, Roman and Pávková Goldbergová, Monika and Kala, Petr and Malásková, Lenka and Čermáková, Zdeňka and Poloczek, Martin and Vytiska, Miroslav and Kubková, Lenka and Helánová, Kateřina and Parenicova, I. and Littnerová, Simona and Dostalova, L. and Kubena, P. and Vašků, Anna and Špinar, Jindřich},
   article_number = {1},
   doi = {http://dx.doi.org/10.5083/ejcm.20424884.67},
   keywords = {aortic pulse pressure; natriuretic peptides; marker},
   language = {eng},
   issn = {2042-4884},
   journal = {EUROPEAN JOURNAL OF CARDIOVASCULAR MEDICINE},
   title = {Determinants of Invasively Measured Aortic Pulse Pressure and its Relationship with B-type Natriuretic Peptides in Stable Patients with Preserved Left Ventricular Systolic Function},
   volume = {11},
   year = {2012}
}

TY  - JOUR
ID  - 980955
AU  - Jarkovský, Jiří - Pařenica, Jiří - Miklík, Roman - Pávková Goldbergová, Monika - Kala, Petr - Malásková, Lenka - Čermáková, Zdeňka - Poloczek, Martin - Vytiska, Miroslav - Kubková, Lenka - Helánová, Kateřina - Parenicova, I. - Littnerová, Simona - Dostalova, L. - Kubena, P. - Vašků, Anna - Špinar, Jindřich
PY  - 2012
TI  - Determinants of Invasively Measured Aortic Pulse Pressure and its Relationship with B-type Natriuretic Peptides in Stable Patients with Preserved Left Ventricular Systolic Function
JF  - EUROPEAN JOURNAL OF CARDIOVASCULAR MEDICINE
VL  - 11
IS  - 1
SP  - 32-40
EP  - 32-40
SN  - 20424884
KW  - aortic pulse pressure
KW  - natriuretic peptides
KW  - marker
N2  - Wide aortic pulse pressure (PP) and levels of natriuretic peptides were repeatedly demonstrated as predictors of cardiovascular morbidity and mortality even in a population without a history of heart disease. The aim of the work was to find determinants of invasively measured aortic pulse pressure and B-type natriuretic peptide (BNP), and a relationship of both markers in stable patients undergoing diagnostic coronary angiography with preserved left ventricle systolic function. Population and methods: A total of 386 stable patients with left ventricle ejection fraction > 50%, without acute myocardial infarction, aortic or mitral valve disease were enrolled. Invasive intra-aortic blood pressure was measured using a fluid-filled catheter in the ascending aorta. Samples of venous blood for analysis of the BNP level were drawn before coronary angiography. Results: We found a positive correlation between aortic systolic blood pressure (SBP) and PP (Pearson’s correlation coefficient = 0.44, p<0.001). Positive relationships were determined among aortic PP and gender, age, BNP, glycaemia, high-density lipoprotein (HDL) cholesterol, hypertension and diabetes mellitus. Negative relationships were found among aortic PP and height, weight and ischemic heart disease, but only gender and age were detected as independent factors in multivariate model. Positive correlation of BNP with age, aortic PP, Left ventricular end diastolic pressure (LVEDP), hypertension, smoking and a negative correlation with creatinine, total cholesterol and ischemic heart disease were shown; only age, creatinine, cholesterol and non- smoker status were independent predictors of BNP value in multivariate model. Conclusion: We found independent determinants of two important predictive markers of cardio-vascular morbidity and mortality – BNP and PP - in group of stable patients.
ER  -

JARKOVSKÝ, Jiří, Jiří PAŘENICA, Roman MIKLÍK, Monika PÁVKOVÁ GOLDBERGOVÁ, Petr KALA, Lenka MALÁSKOVÁ, Zdeňka ČERMÁKOVÁ, Martin POLOCZEK, Miroslav VYTISKA, Lenka KUBKOVÁ, Kateřina HELÁNOVÁ, I. PARENICOVA, Simona LITTNEROVÁ, L. DOSTALOVA, P. KUBENA, Anna VAŠKŮ a Jindřich ŠPINAR. Determinants of Invasively Measured Aortic Pulse Pressure and its Relationship with B-type Natriuretic Peptides in Stable Patients with Preserved Left Ventricular Systolic Function. \textit{EUROPEAN JOURNAL OF CARDIOVASCULAR MEDICINE}. 2012, roč.~11, č.~1, s.~32-40. ISSN~2042-4884. Dostupné z: https://dx.doi.org/10.5083/ejcm.20424884.67.

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