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@proceedings{981939,
author = {Amato, Filippo and PenaandMendez, Eladia Maria and Pivetta, Tiziana and Panyala, Nagender Reddy and Havel, Josef},
booktitle = {4th EuCheMS Chemistry Congress},
keywords = {mass spectrometry; supramolecular aggregates},
language = {eng},
title = {Supramolecular complexes formation. Possibilities of mass spectrometric studies},
url = {http://www.euchems-prague2012.cz/},
year = {2012}
}
TY - CONF
ID - 981939
AU - Amato, Filippo - Pena-Mendez, Eladia Maria - Pivetta, Tiziana - Panyala, Nagender Reddy - Havel, Josef
PY - 2012
TI - Supramolecular complexes formation. Possibilities of mass spectrometric studies
KW - mass spectrometry
KW - supramolecular aggregates
UR - http://www.euchems-prague2012.cz/
L2 - http://www.euchems-prague2012.cz/
N2 - In supramolecular complexes the molecules or ions are held together by non-covalent interactions: Host + Guest <=> {Host, Guest}. Usually, compounds like cyclic ethers, cyclodextrines, or other macrocycles might act as hosts while various organic/inorganic cations, anions, neutral molecules etc. are playing the role of guests. The paper deals with the application of mass spectrometry (MS) for fast screening of variour host-guests combinations in order to find out the formation of supramolecular complexes and/or to search for new potential drug carriers or to decrease their toxicity. MS was done using either matrices, laser desorption ionization (LDI) or surface assisted LDI. Mass spectrometric analysis was used because the reactions can also be done directly on the MS target and several combinations can be examined with the minimum amount of often scarce and expensive reagents. Several examples of supramolecular complex formation using different types of macrocycles (cyclodextrins, cucurbit[n]urils, etc.) as hosts, and either drugs like antivirals, cancerostatics or inorganics including nanoparticles as guests, will be given and discussed. The proposed application of mass spectrometry represents fast, efficient and economic way to search for the formation of new supramolecular complexes. The results might find application in medicine.
ER -
AMATO, Filippo, Eladia Maria PENA-MENDEZ, Tiziana PIVETTA, Nagender Reddy PANYALA a Josef HAVEL. Supramolecular complexes formation. Possibilities of mass spectrometric studies. In \textit{4th EuCheMS Chemistry Congress}. 2012.
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