ŠÁNA, Jiří, Petra FALTEJSKOVÁ, Marek SVOBODA and Ondřej SLABÝ. Novel classes of non-coding RNAs and cancer. Journal of Translational Medicine. London, England: BIOMED CENTRAL LTD, 2012, vol. 10, May, p. "nestránkováno", 21 pp. ISSN 1479-5876. Available from: https://dx.doi.org/10.1186/1479-5876-10-103. |
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@article{983319, author = {Šána, Jiří and Faltejsková, Petra and Svoboda, Marek and Slabý, Ondřej}, article_location = {London, England}, article_number = {May}, doi = {http://dx.doi.org/10.1186/1479-5876-10-103}, keywords = {non-coding RNAs; microRNAs; siRNAs; piRNAs; lncRNAs; cancer}, language = {eng}, issn = {1479-5876}, journal = {Journal of Translational Medicine}, title = {Novel classes of non-coding RNAs and cancer}, url = {http://www.translational-medicine.com/content/pdf/1479-5876-10-103.pdf}, volume = {10}, year = {2012} }
TY - JOUR ID - 983319 AU - Šána, Jiří - Faltejsková, Petra - Svoboda, Marek - Slabý, Ondřej PY - 2012 TI - Novel classes of non-coding RNAs and cancer JF - Journal of Translational Medicine VL - 10 IS - May SP - "nestránkováno" EP - "nestránkováno" PB - BIOMED CENTRAL LTD SN - 14795876 KW - non-coding RNAs KW - microRNAs KW - siRNAs KW - piRNAs KW - lncRNAs KW - cancer UR - http://www.translational-medicine.com/content/pdf/1479-5876-10-103.pdf L2 - http://www.translational-medicine.com/content/pdf/1479-5876-10-103.pdf N2 - For the many years, the central dogma of molecular biology has been that RNA functions mainly as an informational intermediate between a DNA sequence and its encoded protein. But one of the great surprises of modern biology was the discovery that protein-coding genes represent less than 2% of the total genome sequence, and subsequently the fact that at least 90% of the human genome is actively transcribed.Thus, the human transcriptome was found to be more complex than a collection of protein-coding genes and their splice variants. Although initially argued to be spurious transcriptional noise or accumulated evolutionary debris arising from the early assembly of genes and/or the insertion of mobile genetic elements, recent evidence suggests that the non-coding RNAs (ncRNAs) may play major biological roles in cellular development, physiology and pathologies, including cancer. ER -
ŠÁNA, Jiří, Petra FALTEJSKOVÁ, Marek SVOBODA and Ondřej SLABÝ. Novel classes of non-coding RNAs and cancer. \textit{Journal of Translational Medicine}. London, England: BIOMED CENTRAL LTD, 2012, vol.~10, May, p.~''nestránkováno'', 21 pp. ISSN~1479-5876. Available from: https://dx.doi.org/10.1186/1479-5876-10-103.
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