BRÁZDIL, Milan, Radek MAREČEK, Tomáš URBÁNEK, Tomáš KAŠPÁREK, Michal MIKL, Ivan REKTOR and Adam ZEMAN. Unveiling the mystery of déja vu: The structural anatomy of déja vu. Cortex. Milano: Elsevier Masson, vol. 48, No 9, p. 1240-1243. ISSN 0010-9452. doi:10.1016/j.cortex.2012.03.004. 2012.
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Basic information
Original name Unveiling the mystery of déja vu: The structural anatomy of déja vu
Authors BRÁZDIL, Milan (203 Czech Republic, guarantor, belonging to the institution), Radek MAREČEK (203 Czech Republic, belonging to the institution), Tomáš URBÁNEK (203 Czech Republic, belonging to the institution), Tomáš KAŠPÁREK (203 Czech Republic, belonging to the institution), Michal MIKL (203 Czech Republic, belonging to the institution), Ivan REKTOR (203 Czech Republic, belonging to the institution) and Adam ZEMAN (203 Czech Republic).
Edition Cortex, Milano, Elsevier Masson, 2012, 0010-9452.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30000 3. Medical and Health Sciences
Country of publisher Italy
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 6.161
RIV identification code RIV/00216224:14740/12:00060031
Organization unit Central European Institute of Technology
Doi http://dx.doi.org/10.1016/j.cortex.2012.03.004
UT WoS 000308121900013
Keywords in English déja vu; source-based morphometry; temporal lobe epilepsy; neuroanatomy; postnatal neurogenesis
Tags ok, rivok
Tags International impact, Reviewed
Changed by Changed by: Olga Křížová, učo 56639. Changed: 7/4/2013 12:10.
Abstract
Deéja vu (DV) is a widespread, fascinating and mysterious human experience. It occurs both in health and in disease, notably as an aura of temporal lobe epilepsy. This feeling of inappropriate familiarity has attracted interest from psychologists and neuroscientists for over a century, but still there is no widely agreed explanation for the phenomenon of non-pathological DV. Here we investigated differences in brain morphology between healthy subjects with and without DV using a novel multivariate neuroimaging technique, Source-Based Morphometry. The analysis revealed a set of cortical (predominantly mesiotemporal) and subcortical regions in which there was significantly less gray matter in subjects reporting DV. In these regions gray matter volume was inversely correlated with the frequency of DV. Our results demonstrate a structural correlate of DV in healthy individuals for the first time and support a neurological explanation for the phenomenon. We hypothesis that the observed local gray matter decrease in subjects experiencing DV reflects an alteration of hippocampal function and postnatal neurogenesis with resulting changes of volume in remote brain regions.
Links
ED1.1.00/02.0068, research and development projectName: CEITEC - central european institute of technology
MSM0021622404, plan (intention)Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS
Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.
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