Differential effects of modafinil, methamphetamine, and MDMA on agonistic behavior in male mice

MÁCHALOVÁ, Alena, Karel ŠLAIS, Dagmar VRSKOVA and Alexandra ŠULCOVÁ. Differential effects of modafinil, methamphetamine, and MDMA on agonistic behavior in male mice. Pharmacology Biochemistry and Behavior. Oxford, UK: Elsevier Science Inc., 2012, vol. 102, No 2, p. 215-223. ISSN 0091-3057. Available from: https://dx.doi.org/10.1016/j.pbb.2012.04.013.

Basic information

• Original name: Differential effects of modafinil, methamphetamine, and MDMA on agonistic behavior in male mice
• Authors: MÁCHALOVÁ, Alena (203 Czech Republic, belonging to the institution), Karel ŠLAIS (203 Czech Republic, belonging to the institution), Dagmar VRSKOVA (203 Czech Republic) and Alexandra ŠULCOVÁ (203 Czech Republic, guarantor, belonging to the institution).
• Edition: Pharmacology Biochemistry and Behavior, Oxford, UK, Elsevier Science Inc. 2012, 0091-3057.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30000 3. Medical and Health Sciences
• Country of publisher: United Kingdom of Great Britain and Northern Ireland
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Impact factor: Impact factor: 2.608
• RIV identification code: RIV/00216224:14740/12:00060033
• Organization unit: Central European Institute of Technology
• Doi: http://dx.doi.org/10.1016/j.pbb.2012.04.013
• UT WoS: 000306776000006
• Keywords in English: Psychostimulant; Modafinill; Methamphetamine; MDMA; Agnostic behavior; Mice
• Tags: ok, rivok
• Tags: International impact, Reviewed

Abstract

The aim of the present study was to compare the behavioral effects of modafinil, an atypical psychostimulatory acting and cognitive-function improving drug, with the effects of the psychostimulants methamphetamine (MET) and MDMA (3,4-methylenedioxymethamphetamine, or “ecstasy”) in a model of mouse agonistic behavior. This model enables the observation of ethologically well-defined sociable, timid, aggressive, and locomotor behavioral acts and postures. Singly-housed male mice (isolates)were separated into 4 groups. The observations were performed in 4 sessions, 1 week apart. In each interaction, singly-housed mice were paired with nonaggressive group-housed partners for 4 min in a neutral environment. The isolates received, in a Latin square design, either a) a vehicle or modafinil at doses 2.0, 10.0, or 50.0 mg/kg; or b) a vehicle or MET at doses 1.0, 5.0, or 10.0 mg/kg; or c) a vehicle or MDMA at doses 2.5, 10.0, or 30.0 mg/kg. The isolates were categorized as timid or aggressive according to their behavior in the control interaction (vehicle pre-treatment). Elements of locomotor, sociable, aggressive, and timid behavior were evaluated (one-way ANOVA).

Links

• ED1.1.00/02.0068, research and development project: Name: CEITEC - central european institute of technology
• MSM0021622404, plan (intention): Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.