Differential effects of modafinil, methamphetamine, and MDMA on
agonistic behavior in male mice

J 2012

Differential effects of modafinil, methamphetamine, and MDMA on agonistic behavior in male mice

MÁCHALOVÁ, Alena, Karel ŠLAIS, Dagmar VRSKOVA a Alexandra ŠULCOVÁ

Základní údaje

Originální název

Differential effects of modafinil, methamphetamine, and MDMA on agonistic behavior in male mice

Autoři

MÁCHALOVÁ, Alena (203 Česká republika, domácí), Karel ŠLAIS (203 Česká republika, domácí), Dagmar VRSKOVA (203 Česká republika) a Alexandra ŠULCOVÁ (203 Česká republika, garant, domácí)

Vydání

Pharmacology Biochemistry and Behavior, Oxford, UK, Elsevier Science Inc. 2012, 0091-3057

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.608

Kód RIV

RIV/00216224:14740/12:00060033

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.1016/j.pbb.2012.04.013

UT WoS

000306776000006

Klíčová slova anglicky

Psychostimulant; Modafinill; Methamphetamine; MDMA; Agnostic behavior; Mice

Štítky

ok, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 7. 4. 2013 08:09, Olga Křížová

Anotace

V originále

The aim of the present study was to compare the behavioral effects of modafinil, an atypical psychostimulatory acting and cognitive-function improving drug, with the effects of the psychostimulants methamphetamine (MET) and MDMA (3,4-methylenedioxymethamphetamine, or “ecstasy”) in a model of mouse agonistic behavior. This model enables the observation of ethologically well-defined sociable, timid, aggressive, and locomotor behavioral acts and postures. Singly-housed male mice (isolates)were separated into 4 groups. The observations were performed in 4 sessions, 1 week apart. In each interaction, singly-housed mice were paired with nonaggressive group-housed partners for 4 min in a neutral environment. The isolates received, in a Latin square design, either a) a vehicle or modafinil at doses 2.0, 10.0, or 50.0 mg/kg; or b) a vehicle or MET at doses 1.0, 5.0, or 10.0 mg/kg; or c) a vehicle or MDMA at doses 2.5, 10.0, or 30.0 mg/kg. The isolates were categorized as timid or aggressive according to their behavior in the control interaction (vehicle pre-treatment). Elements of locomotor, sociable, aggressive, and timid behavior were evaluated (one-way ANOVA).

Návaznosti

ED1.1.00/02.0068, projekt VaV

Název: CEITEC - central european institute of technology

MSM0021622404, záměr

Název: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Citovat

MÁCHALOVÁ, Alena, Karel ŠLAIS, Dagmar VRSKOVA a Alexandra ŠULCOVÁ. Differential effects of modafinil, methamphetamine, and MDMA on agonistic behavior in male mice. Pharmacology Biochemistry and Behavior. Oxford, UK: Elsevier Science Inc., 2012, roč. 102, č. 2, s. 215-223. ISSN 0091-3057. Dostupné z: https://dx.doi.org/10.1016/j.pbb.2012.04.013.

@article{983340,
   author = {Máchalová, Alena and Šlais, Karel and Vrskova, Dagmar and Šulcová, Alexandra},
   article_location = {Oxford, UK},
   article_number = {2},
   doi = {http://dx.doi.org/10.1016/j.pbb.2012.04.013},
   keywords = {Psychostimulant; Modafinill; Methamphetamine; MDMA; Agnostic behavior; Mice},
   language = {eng},
   issn = {0091-3057},
   journal = {Pharmacology Biochemistry and Behavior},
   title = {Differential effects of modafinil, methamphetamine, and MDMA on agonistic behavior in male mice},
   url = {http://www.sciencedirect.com/science/article/pii/S0091305712001232},
   volume = {102},
   year = {2012}
}

TY  - JOUR
ID  - 983340
AU  - Máchalová, Alena - Šlais, Karel - Vrskova, Dagmar - Šulcová, Alexandra
PY  - 2012
TI  - Differential effects of modafinil, methamphetamine, and MDMA on agonistic behavior in male mice
JF  - Pharmacology Biochemistry and Behavior
VL  - 102
IS  - 2
SP  - 215-223
EP  - 215-223
PB  - Elsevier Science Inc.
SN  - 00913057
KW  - Psychostimulant
KW  - Modafinill
KW  - Methamphetamine
KW  - MDMA
KW  - Agnostic behavior
KW  - Mice
UR  - http://www.sciencedirect.com/science/article/pii/S0091305712001232
L2  - http://www.sciencedirect.com/science/article/pii/S0091305712001232
N2  - The aim of the present study was to compare the behavioral effects of modafinil, an atypical psychostimulatory acting and cognitive-function improving drug, with the effects of the psychostimulants methamphetamine (MET) and MDMA (3,4-methylenedioxymethamphetamine, or “ecstasy”) in a model of mouse agonistic behavior. This model enables the observation of ethologically well-defined sociable, timid, aggressive, and locomotor behavioral acts and postures. Singly-housed male mice (isolates)were separated into 4 groups. The observations were performed in 4 sessions, 1 week apart. In each interaction, singly-housed mice were paired with nonaggressive group-housed partners for 4 min in a neutral environment. The isolates received, in a Latin square design, either a) a vehicle or modafinil at doses 2.0, 10.0, or 50.0 mg/kg; or b) a vehicle or MET at doses 1.0, 5.0, or 10.0 mg/kg; or c) a vehicle or MDMA at doses 2.5, 10.0, or 30.0 mg/kg. The isolates were categorized as timid or aggressive according to their behavior in the control interaction (vehicle pre-treatment). Elements of locomotor, sociable, aggressive, and timid behavior were evaluated (one-way ANOVA).
ER  -

MÁCHALOVÁ, Alena, Karel ŠLAIS, Dagmar VRSKOVA a Alexandra ŠULCOVÁ. Differential effects of modafinil, methamphetamine, and MDMA on agonistic behavior in male mice. \textit{Pharmacology Biochemistry and Behavior}. Oxford, UK: Elsevier Science Inc., 2012, roč.~102, č.~2, s.~215-223. ISSN~0091-3057. Dostupné z: https://dx.doi.org/10.1016/j.pbb.2012.04.013.

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