HLA-G and HLA-E specific mRNAs connote opposite prognostic
significance in renal cell carcinoma

J 2012

HLA-G and HLA-E specific mRNAs connote opposite prognostic significance in renal cell carcinoma

KŘEN, Leoš, Ivo VALKOVSKÝ, Jan DOLEŽEL, Ivo ČAPÁK, Dalibor PACÍK et. al.

Základní údaje

Originální název

HLA-G and HLA-E specific mRNAs connote opposite prognostic significance in renal cell carcinoma

Autoři

KŘEN, Leoš (203 Česká republika, garant, domácí), Ivo VALKOVSKÝ (203 Česká republika), Jan DOLEŽEL (203 Česká republika), Ivo ČAPÁK (203 Česká republika), Dalibor PACÍK (203 Česká republika, domácí), Alexandr POPRACH (203 Česká republika), Radek LAKOMÝ (203 Česká republika), Martina RÉDOVÁ (203 Česká republika, domácí), Pavel FABIAN (203 Česká republika), Zdenka KŘENOVÁ (203 Česká republika, domácí) a Ondřej SLABÝ (203 Česká republika, domácí)

Vydání

Diagnostic Pathology, LONDON, BIOMED CENTRAL LTD, 2012, 1746-1596

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30200 3.2 Clinical medicine

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 1.850

Kód RIV

RIV/00216224:14110/12:00060120

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1186/1746-1596-7-58

UT WoS

000306977900001

Klíčová slova anglicky

renal cell carcinoma; radiotherapy; chemotherapy; HLA-G; HLA-E

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 22. 4. 2013 18:23, Soňa Böhmová

Anotace

V originále

Background: Renal cell carcinoma (RCC) is characterized by its resistance to radiotherapy and/or chemotherapy. On the other hand, it is an immunogenic tumor - it is able to stimulate antitumor responses. A prognostic significance of HLA-G expression by neoplastic cells in RCC is not well characterized; significance HLA-E expression in RCC is not characterized at all. Methods: In our study, we evaluated the expression of HLA-G and HLA-E specific mRNA transcripts produced by neoplastic cells in 38 cases of RCC and in 10 samples of normal kidney parenchyma. The results were statistically correlated with various clinico-pathological parameters. Results: We confirmed that HLA-G is downregulated in normal kidney tissue; if it is up-regulated in RCC, then it is connected to worse prognosis. On the other hand, HLA-E mRNA transcripts were present in both normal kidney tissue and RCC and their increasing concentrations counterintuitively carried better prognosis, more favorable pT stage and lower nuclear Fuhrmann's grade. Conclusion: Considering the fact that there is known aberrant activation of HLA-G and HLA-E expression by interferons, identification of HLA-G and HLA-E status could contribute to better selection of RCC patients who could possibly benefit from more tailored neoadjuvant biological/immunological therapy. Thus, these molecules could represent useful prognostic biomarkers in RCC, and the expression of both these molecules in RCC deserves further study. The virtual: Slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/7383071387016614

Návaznosti

ED1.1.00/02.0068, projekt VaV

Název: CEITEC - central european institute of technology

Citovat

KŘEN, Leoš, Ivo VALKOVSKÝ, Jan DOLEŽEL, Ivo ČAPÁK, Dalibor PACÍK, Alexandr POPRACH, Radek LAKOMÝ, Martina RÉDOVÁ, Pavel FABIAN, Zdenka KŘENOVÁ a Ondřej SLABÝ. HLA-G and HLA-E specific mRNAs connote opposite prognostic significance in renal cell carcinoma. Diagnostic Pathology. LONDON: BIOMED CENTRAL LTD, 2012, roč. 7, č. 1, s. 58-64. ISSN 1746-1596. Dostupné z: https://dx.doi.org/10.1186/1746-1596-7-58.

@article{984207,
   author = {Křen, Leoš and Valkovský, Ivo and Doležel, Jan and Čapák, Ivo and Pacík, Dalibor and Poprach, Alexandr and Lakomý, Radek and Rédová, Martina and Fabian, Pavel and Křenová, Zdenka and Slabý, Ondřej},
   article_location = {LONDON},
   article_number = {1},
   doi = {http://dx.doi.org/10.1186/1746-1596-7-58},
   keywords = {renal cell carcinoma; radiotherapy; chemotherapy; HLA-G; HLA-E},
   language = {eng},
   issn = {1746-1596},
   journal = {Diagnostic Pathology},
   title = {HLA-G and HLA-E specific mRNAs connote opposite prognostic significance in renal cell carcinoma},
   url = {http://www.diagnosticpathology.org/content/pdf/1746-1596-7-58.pdf},
   volume = {7},
   year = {2012}
}

TY  - JOUR
ID  - 984207
AU  - Křen, Leoš - Valkovský, Ivo - Doležel, Jan - Čapák, Ivo - Pacík, Dalibor - Poprach, Alexandr - Lakomý, Radek - Rédová, Martina - Fabian, Pavel - Křenová, Zdenka - Slabý, Ondřej
PY  - 2012
TI  - HLA-G and HLA-E specific mRNAs connote opposite prognostic significance in renal cell carcinoma
JF  - Diagnostic Pathology
VL  - 7
IS  - 1
SP  - 58
EP  - 58
PB  - BIOMED CENTRAL LTD
SN  - 17461596
KW  - renal cell carcinoma
KW  - radiotherapy
KW  - chemotherapy
KW  - HLA-G
KW  - HLA-E
UR  - http://www.diagnosticpathology.org/content/pdf/1746-1596-7-58.pdf
N2  - Background: Renal cell carcinoma (RCC) is characterized by its resistance to radiotherapy and/or chemotherapy. On the other hand, it is an immunogenic tumor - it is able to stimulate antitumor responses. A prognostic significance of HLA-G expression by neoplastic cells in RCC is not well characterized; significance HLA-E expression in RCC is not characterized at all. Methods: In our study, we evaluated the expression of HLA-G and HLA-E specific mRNA transcripts produced by neoplastic cells in 38 cases of RCC and in 10 samples of normal kidney parenchyma. The results were statistically correlated with various clinico-pathological parameters. Results: We confirmed that HLA-G is downregulated in normal kidney tissue; if it is up-regulated in RCC, then it is connected to worse prognosis. On the other hand, HLA-E mRNA transcripts were present in both normal kidney tissue and RCC and their increasing concentrations counterintuitively carried better prognosis, more favorable pT stage and lower nuclear Fuhrmann's grade. Conclusion: Considering the fact that there is known aberrant activation of HLA-G and HLA-E expression by interferons, identification of HLA-G and HLA-E status could contribute to better selection of RCC patients who could possibly benefit from more tailored neoadjuvant biological/immunological therapy. Thus, these molecules could represent useful prognostic biomarkers in RCC, and the expression of both these molecules in RCC deserves further study. The virtual: Slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/7383071387016614
ER  -

KŘEN, Leoš, Ivo VALKOVSKÝ, Jan DOLEŽEL, Ivo ČAPÁK, Dalibor PACÍK, Alexandr POPRACH, Radek LAKOMÝ, Martina RÉDOVÁ, Pavel FABIAN, Zdenka KŘENOVÁ a Ondřej SLABÝ. HLA-G and HLA-E specific mRNAs connote opposite prognostic significance in renal cell carcinoma. \textit{Diagnostic Pathology}. LONDON: BIOMED CENTRAL LTD, 2012, roč.~7, č.~1, s.~58-64. ISSN~1746-1596. Dostupné z: https://dx.doi.org/10.1186/1746-1596-7-58.

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