RÉDOVÁ, Martina, Ondřej SLABÝ, Radek LAKOMÝ, Alexandr POPRACH, Jan HODEK, Marek SVOBODA, Lenka RADOVÁ, Pavel FABIAN, Robert ILIEV, Jaroslava OVESNÁ, Jaroslav MICHÁLEK and Rostislav VYZULA. MicroRNA in renal cell carcinoma – potential marker for prediction of early metastasis after nephrectomy. In The Student Scientific Conference on Cancer Research. 2011. ISBN 978-80-210-5442-4.
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Basic information
Original name MicroRNA in renal cell carcinoma – potential marker for prediction of early metastasis after nephrectomy.
Authors RÉDOVÁ, Martina, Ondřej SLABÝ, Radek LAKOMÝ, Alexandr POPRACH, Jan HODEK, Marek SVOBODA, Lenka RADOVÁ, Pavel FABIAN, Robert ILIEV, Jaroslava OVESNÁ, Jaroslav MICHÁLEK and Rostislav VYZULA.
Edition The Student Scientific Conference on Cancer Research, 2011.
Other information
Original language English
Type of outcome Conference abstract
Field of Study 30200 3.2 Clinical medicine
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
Organization unit Masaryk Memorial Cancer Institute
ISBN 978-80-210-5442-4
Keywords in English microRNA; renal cell carcinoma; metastasis; nephrectomy
Changed by Changed by: Mgr. Petra Vychytilová, Ph.D., učo 211789. Changed: 7/6/2012 13:21.
Abstract
Renal cell carcinoma (RCC) is the most common neoplasma of the adult kidney accounting for about 3 % of adult malignancies. RCC originates in the lining of the proximal renal tubule. The clear cell histology type, renal clear cell carcinoma (RCCC), is approximately 80-85%) of metastatic RCC and the most frequent subtype of RCC. Although surgigal resection remains the best curative therapy for RCC, after the curative nephrectomy, 20-40% patients will develope recurrence. Moreover, the absence of biomarkers for early detection and follow-up of the disease complicate the on-time diagnosis. For these reasons, it is worth revealing the underlying molecular and genetic mechanisms for RCC initiation and development, and finding new biomarkers which would enable prediction of early metastasis after curative nephrectomy.
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