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@book{984805,
author = {Slabý, Ondřej},
address = {New York},
keywords = {microRNAs; solid cancer; biomarkers; therapeutic targets},
howpublished = {tištěná verze "print"},
language = {eng},
location = {New York},
isbn = {978-1-61324-514-9},
note = {nelze odvést do RIV - byly vykázány jednotlivé kapitoly},
publisher = {Nova Science Publishers, Inc.},
title = {MicroRNAs in Solid Cancer: From Biomarkers to Therapeutic Targets},
year = {2012}
}
TY - BOOK
ID - 984805
AU - Slabý, Ondřej
PY - 2012
TI - MicroRNAs in Solid Cancer: From Biomarkers to Therapeutic Targets
VL - Neuveden
PB - Nova Science Publishers, Inc.
CY - New York
SN - 9781613245149
N1 - nelze odvést do RIV - byly vykázány jednotlivé kapitoly
KW - microRNAs
KW - solid cancer
KW - biomarkers
KW - therapeutic targets
N2 - MiRNA is extremely fast growing field, and miRNA knowledge is now believed to be a pivotal element of cancer biology. An individual miRNA interferes with a broad range of mRNAs; conversely, a single mRNA could be targeted by a variety of miRNAs. The complexity of miRNA:mRNA interaction is far-reaching and a bit beyond our understanding to date. It is already evident that the discovery of miRNA has created a paradigm shift in post-genomics biology, not only for scientists accustomed to traditional central dogma of molecular biology but also for researchers studying human diseases and accustomed to traditional genetics approach of studying one gene at the time. The ability of miRNAs to control large groups of genes and impose global post-transcriptional regulation of many (if not all) important cellular processes in development, cell proliferation and differentiation has opened up a new dimension and uncovered complexity of intracellular regulatory processes. This book is expected to provide introduction to the basic principles of miRNA biology, overview of miRNA significance in the hallmarks of cancer, experimental techniques used in miRNA research, and in special part - miRNAs importance in wide range of solid cancers with a special focus on its potential usage in molecular pathology, predictive oncology or as a novel therapeutic targets.
ER -
SLABÝ, Ondřej. \textit{MicroRNAs in Solid Cancer: From Biomarkers to Therapeutic Targets}. New York: Nova Science Publishers, Inc., 2012, 192 s. ISBN~978-1-61324-514-9.
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