ŠÁNA, Jiří. MicroRNAs and Prostate Cancer. In MicroRNAs in Solid Cancer: From Biomarkers to Therapeutic Targets. New York: Nova Science Publishers, Inc., 2012, p. 111-120. ISBN 978-1-61324-514-9.
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Basic information
Original name MicroRNAs and Prostate Cancer
Authors ŠÁNA, Jiří.
Edition New York, MicroRNAs in Solid Cancer: From Biomarkers to Therapeutic Targets, p. 111-120, 10 pp. 2012.
Publisher Nova Science Publishers, Inc.
Other information
Original language English
Type of outcome Chapter(s) of a specialized book
Field of Study 30200 3.2 Clinical medicine
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
Organization unit Masaryk Memorial Cancer Institute
ISBN 978-1-61324-514-9
Keywords in English microRNAs; prostate cancer
Tags International impact, Reviewed
Changed by Changed by: Mgr. Petra Vychytilová, Ph.D., učo 211789. Changed: 11/6/2012 17:04.
Abstract
Prostate cancer is the most frequently diagnosed cancer in men in Western countries. The mechanisms initiating and subsequently supporting growth of this cancer remain largely unknown. Results from recent studies indicate that miRNA expression profiles may distinguish prostate carcinoma from non-neoplastic specimens and further classify tumors according to androgen dependence. In addition, a prognostic significance was attributed to specific miRNA patterns as predictors of clinical recurrence following radical prostatectomy. Finally, therapeutic potential of selected miRNAs were tested on in vitro and in vivo models indicating promising results. This chapter summarizes the current knowledge about miRNA deregulation in prostate cancer disease.
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