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@inbook{984818, author = {Slabý, Ondřej}, address = {New York}, booktitle = {MicroRNAs in Solid Cancer: From Biomarkers to Therapeutic Targets}, editor = {Ondrej Slaby}, keywords = {microRNAs; cancer; genetic polymorphisms}, howpublished = {tištěná verze "print"}, language = {eng}, location = {New York}, isbn = {978-1-61324-514-9}, pages = {21-28}, publisher = {Nova Science Publishers, Inc.}, title = {MicroRNAs and Genetic Polymorphisms in Cancer}, year = {2012} }
TY - CHAP ID - 984818 AU - Slabý, Ondřej PY - 2012 TI - MicroRNAs and Genetic Polymorphisms in Cancer VL - Neuveden PB - Nova Science Publishers, Inc. CY - New York SN - 9781613245149 KW - microRNAs KW - cancer KW - genetic polymorphisms N2 - Single nucleotide polymorphisms (SNPs) may occur at the level of miRNA biogenesis pathway genes, pri-miRNA, pre-miRNA or the mature miRNA sequence. Such SNPs may be functional in the biogenesis and action of the mature miRNA. SNPs located to predicted miRNA target sites within 3' UTR of mRNAs have the potential to affect the efficiency of miRNA binding on its target site, create or destroy binding sites. Resulting gene deregulation can involve changes in phenotype and be eventually critical not only for the susceptibility and the onset of cancer, but also for its prognosis and therapy response prediction. ER -
SLABÝ, Ondřej. MicroRNAs and Genetic Polymorphisms in Cancer. In Ondrej Slaby. \textit{MicroRNAs in Solid Cancer: From Biomarkers to Therapeutic Targets}. New York: Nova Science Publishers, Inc., 2012, s.~21-28. ISBN~978-1-61324-514-9.
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