C 2012

MicroRNA and Glial Tumors: Tiny Relation with Great Potential

ŠÁNA, Jiří, Marian HAJDÚCH and Ondřej SLABÝ

Basic information

Original name

MicroRNA and Glial Tumors: Tiny Relation with Great Potential

Authors

ŠÁNA, Jiří (203 Czech Republic, guarantor, belonging to the institution), Marian HAJDÚCH (203 Czech Republic) and Ondřej SLABÝ (203 Czech Republic, belonging to the institution)

Edition

Neuveden, Novel Therapeutic Concepts in Targeting Glioma, p. 59-74, 16 pp. 2012

Publisher

InTech

Other information

Language

English

Type of outcome

Kapitola resp. kapitoly v odborné knize

Field of Study

30200 3.2 Clinical medicine

Country of publisher

Croatia

Confidentiality degree

není předmětem státního či obchodního tajemství

Publication form

printed version "print"

References:

RIV identification code

RIV/00216224:14740/12:00060177

Organization unit

Central European Institute of Technology

ISBN

978-953-51-0491-9

DOI

Keywords in English

microRNAs; glial tumors

Tags

Tags

International impact, Reviewed
Změněno: 10/4/2013 00:43, Olga Křížová

Abstract

V originále

MicroRNAs (miRNAs) are endogenously expressed small non-coding RNAs that act as post-transcriptional regulators of gene expression. Dysregulation of these molecules has been observed in many types of cancers. Altered expression levels of several miRNAs were identified also in gliomas. It was many times showed that miRNAs are involved in core signaling pathways, which play roles in crucial cellular processes, such as proliferation, apoptosis, cell cycle regulation, invasion, angiogenesis and stem cell behaviour. Therefore, miRNAs have a great potential for oncodiagnostic as well as could be promising therapeutic targets in gliomas.

Links

ED1.1.00/02.0068, research and development project
Name: CEITEC - central european institute of technology