Cyclin K goes with Cdk12 and Cdk13

J 2012

Cyclin K goes with Cdk12 and Cdk13

KOHOUTEK, Jiří a Dalibor BLAŽEK

Základní údaje

Originální název

Cyclin K goes with Cdk12 and Cdk13

Autoři

KOHOUTEK, Jiří (203 Česká republika) a Dalibor BLAŽEK (203 Česká republika, garant, domácí)

Vydání

Cell Division, London, Biomed Central Ltd. 2012, 1747-1028

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

Genetika a molekulární biologie

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.471

Kód RIV

RIV/00216224:14740/12:00057443

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.1186/1747-1028-7-12

UT WoS

000303827600001

Klíčová slova anglicky

Transcription; Posttranscriptional processing; DNA damage; P-TEFb; Cyclin L; CTD code; CTD kinase; Phosphorylation of serine 2; BRCA1; ATR; FANCI; FANCD2

Štítky

ok, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 7. 4. 2013 05:28, Olga Křížová

Anotace

V originále

The cyclin-dependent kinases (Cdks) regulate many cellular processes, including the cell cycle, neuronal development, transcription, and posttranscriptional processing. To perform their functions, Cdks bind to specific cyclin subunits to form a functional and active cyclin/Cdk complex. This review is focused on Cyclin K, which was originally considered an alternative subunit of Cdk9, and on its newly identified partners, Cdk12 and Cdk13. We briefly summarize research devoted to each of these proteins. We also discuss the proteins’ functions in the regulation of gene expression via the phosphorylation of serine 2 in the C-terminal domain of RNA polymerase II, contributions to the maintenance of genome stability, and roles in the onset of human disease and embryo development.

Návaznosti

ED1.1.00/02.0068, projekt VaV

Název: CEITEC - central european institute of technology

GAP305/11/1564, projekt VaV

Název: Nová izoforma cyklinu K je partnerem kinázy cdk12 regulující transkripci a alternativní sestřih u eukaryot

Investor: Grantová agentura ČR, Nová izoforma cyklinu K je partnerem kinázy cdk12 regulující transkripci a alternativní sestřih u eukaryot

SRGA454, interní kód MU

Název: Regulace a funkce P-TEFb komplexů (Akronym: P-TEFb)

Investor: Jihomoravský kraj, Regulace a funkce P-TEFb komplexů, Reintegrační granty

Citovat

KOHOUTEK, Jiří a Dalibor BLAŽEK. Cyclin K goes with Cdk12 and Cdk13. Cell Division. London: Biomed Central Ltd., 2012, roč. 7, č. 12, s. "nestránkováno", 10 s. ISSN 1747-1028. Dostupné z: https://dx.doi.org/10.1186/1747-1028-7-12.

@article{984838,
   author = {Kohoutek, Jiří and Blažek, Dalibor},
   article_location = {London},
   article_number = {12},
   doi = {http://dx.doi.org/10.1186/1747-1028-7-12},
   keywords = {Transcription; Posttranscriptional processing; DNA damage; P-TEFb; Cyclin L; CTD code; CTD kinase; Phosphorylation of serine 2; BRCA1; ATR; FANCI; FANCD2},
   language = {eng},
   issn = {1747-1028},
   journal = {Cell Division},
   title = {Cyclin K goes with Cdk12 and Cdk13},
   url = {http://www.celldiv.com/content/7/1/12},
   volume = {7},
   year = {2012}
}

TY  - JOUR
ID  - 984838
AU  - Kohoutek, Jiří - Blažek, Dalibor
PY  - 2012
TI  - Cyclin K goes with Cdk12 and Cdk13
JF  - Cell Division
VL  - 7
IS  - 12
SP  - "nestránkováno"
EP  - "nestránkováno"
PB  - Biomed Central Ltd.
SN  - 17471028
KW  - Transcription
KW  - Posttranscriptional processing
KW  - DNA damage
KW  - P-TEFb
KW  - Cyclin L
KW  - CTD code
KW  - CTD kinase
KW  - Phosphorylation of serine 2
KW  - BRCA1
KW  - ATR
KW  - FANCI
KW  - FANCD2
UR  - http://www.celldiv.com/content/7/1/12
L2  - http://www.celldiv.com/content/7/1/12
N2  - The cyclin-dependent kinases (Cdks) regulate many cellular processes, including the cell cycle, neuronal development, transcription, and posttranscriptional processing. To perform their functions, Cdks bind to specific cyclin subunits to form a functional and active cyclin/Cdk complex. This review is focused on Cyclin K, which was originally considered an alternative subunit of Cdk9, and on its newly identified partners, Cdk12 and Cdk13. We briefly summarize research devoted to each of these proteins. We also discuss the proteins’ functions in the regulation of gene expression via the phosphorylation of serine 2 in the C-terminal domain of RNA polymerase II, contributions to the maintenance of genome stability, and roles in the onset of human disease and embryo development.
ER  -

KOHOUTEK, Jiří a Dalibor BLAŽEK. Cyclin K goes with Cdk12 and Cdk13. \textit{Cell Division}. London: Biomed Central Ltd., 2012, roč.~7, č.~12, s.~''nestránkováno'', 10 s. ISSN~1747-1028. Dostupné z: https://dx.doi.org/10.1186/1747-1028-7-12.

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