MicroRNAs in Colorectal Cancer

SLABÝ, Ondřej, Marek SVOBODA, Jaroslav MICHÁLEK a Rostislav VYZULA. MicroRNAs in Colorectal Cancer. In MicroRNAs in Cancer Translational Research. 1st ed. Springer, 2011, s. 107-133. ISBN 978-94-007-0297-4.

Základní údaje

Originální název

MicroRNAs in Colorectal Cancer

Autoři

SLABÝ, Ondřej, Marek SVOBODA, Jaroslav MICHÁLEK a Rostislav VYZULA

Vydání

1st ed. MicroRNAs in Cancer Translational Research, od s. 107-133, 27 s. 2011

Nakladatel

Springer

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Další údaje

Jazyk

angličtina

Typ výsledku

Kapitola resp. kapitoly v odborné knize

Obor

30200 3.2 Clinical medicine

Stát vydavatele

Německo

Utajení

není předmětem státního či obchodního tajemství

Organizační jednotka

Lékařská fakulta

ISBN

978-94-007-0297-4

Klíčová slova anglicky

microRNAs; colorectal cancer

Příznaky

Mezinárodní význam, Recenzováno

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Anotace

V originále

Colorectal cancer (CRC) represents one of the most frequent causes of death for cancer. CRC has been recently defined as the third most common cancer. MicroRNAs (miRNAs) are a class of small interfering RNAs frequently involved in the pathogenesis of cancer. Polymorphisms within miRNAs binding regions have been described as new risk factors for CRC. Several genome-wide profiling studies have identified miRNAs deregulated in CRC tissue. A number of experimental studies on these miRNAs revealed insight into miRNA-mediated regulatory links to well-known oncogenic and tumor suppressor signaling pathways. Several investigations have also described the ability of specific miRNA expression profiles to predict prognosis and therapy response in CRC patients. In this chapter, we focus on the most significant findings of original studies on miRNAs involvemenet in CRC pathogenesis, focusing also on the potential of cancer-related miRNAs as biomarkers for diagnosis, prognosis, prediction, and therapeutical targets.