SVOBODA, Marek, Ondřej SLABÝ, Renata HÉŽOVÁ, Pavel FABIAN, Ilona KOCÁKOVÁ, Barbora ONDROVÁ and Rostislav VYZULA. MicroRNA profiling in predictive oncology of colorectal cancer. In RNAi & miRNA World Congess, Epigenetics World Congress, Genomics Automation Congress, Boston. 2010.
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Basic information
Original name MicroRNA profiling in predictive oncology of colorectal cancer.
Authors SVOBODA, Marek, Ondřej SLABÝ, Renata HÉŽOVÁ, Pavel FABIAN, Ilona KOCÁKOVÁ, Barbora ONDROVÁ and Rostislav VYZULA.
Edition RNAi & miRNA World Congess, Epigenetics World Congress, Genomics Automation Congress, Boston, 2010.
Other information
Original language English
Type of outcome Conference abstract
Field of Study 30200 3.2 Clinical medicine
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
Organization unit Masaryk Memorial Cancer Institute
Keywords in English microRNAs; colorectal cancer; fluoropyrimidine-based chemoradiotherapy
Tags International impact
Changed by Changed by: Mgr. Petra Vychytilová, Ph.D., učo 211789. Changed: 12/6/2012 14:14.
Abstract
Fluoropyrimidine-base chemoradiotherapy before total mesorectal excision (TME) is currently the gold standard treatment for stage II and III rectal cancer patients. Pathological complete response is related with a longer relaps and overall survival. On the other hand, patients with a primary resistant tumors could be spared exposure to chemotherapy and radiation that are associated with substantial adverse effects and costs, and surgery could be schduled without delay. We have used microRNA profilling to identify in our series responders and non responders to preoperative treatment.
Links
NR9076, research and development projectName: Genomické profilování v predikci odpovědi na chemoradioterapii u pacientů s lokálně pokročilým karcinomem konečníku
NS10352, research and development projectName: Význam mikroRNA v chemoprotektivním účinku fytochemikálií zeleniny rodu Brassica a vliv polymorfizmů jejich vazebných míst na riziko nádorového onemocnění tlustého střeva a konečníku
NS9814, research and development projectName: Identifikace a studium funkce mikroRNA s prediktivním a prognostickým významen u pacientů se zhoubným novotvarem tlustého střeva a konečníku
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