Electrochemical Study of Doxorubicin Interaction with Different
Sequences of Double Stranded Oligonucleotides, Part II

J 2012

Electrochemical Study of Doxorubicin Interaction with Different Sequences of Double Stranded Oligonucleotides, Part II

HYNEK, David, Ludmila KREJČOVÁ, Ondřej ZÍTKA, Vojtěch ADAM, Libuše TRNKOVÁ et. al.

Základní údaje

Originální název

Electrochemical Study of Doxorubicin Interaction with Different Sequences of Double Stranded Oligonucleotides, Part II

Autoři

HYNEK, David (203 Česká republika), Ludmila KREJČOVÁ (203 Česká republika), Ondřej ZÍTKA (203 Česká republika), Vojtěch ADAM (203 Česká republika), Libuše TRNKOVÁ (203 Česká republika, domácí), Jiří SOCHOR (203 Česká republika), Marie STIBOROVÁ (203 Česká republika), Tomáš ECKSCHLAGER (203 Česká republika), Jaromír HUBÁLEK (203 Česká republika) a René KIZEK (203 Česká republika, garant)

Vydání

International Journal of Electrochemical Science, 2012, 1452-3981

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10403 Physical chemistry

Stát vydavatele

Srbsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 3.729 v roce 2011

Kód RIV

RIV/00216224:14310/12:00060307

Organizační jednotka

Přírodovědecká fakulta

UT WoS

000302723700003

Klíčová slova anglicky

intercalating drug; doxorubicin; hetero-nucleotides; square wave voltammetry; adsorptive transfer stripping technique; adriamycin; DNA

Štítky

AKR, rivok

Změněno: 9. 1. 2013 10:24, Mgr. Sylvie Dohnalíková

Anotace

V originále

Interaction of low molecular weight compounds with DNA is one of general mechanisms utilized for an effective anticancer therapy. The anthracycline doxorubicin is one of the drugs that represent the compound with such effect. In our previous work [Hynek et al., Int. J. Electrochem, Sci. 7 (2012) xx] the electrochemical behaviour of doxorubicin interaction with single stranded ODN by using adsorptive transfer stripping square wave voltammetry was described. This paper is focused on the study of interaction of doxorubicin with double stranded ODNs (dsODNs) using the same technique. Here, we used four dsODNs possessing different primary structuresand observed the changes in their electrochemical behaviour after their treatment with three concentrations of doxorubicin for 5 hours. The changes found are discussed and differences in behaviours of individual dsODNs described and associated with their structure.

Citovat

HYNEK, David, Ludmila KREJČOVÁ, Ondřej ZÍTKA, Vojtěch ADAM, Libuše TRNKOVÁ, Jiří SOCHOR, Marie STIBOROVÁ, Tomáš ECKSCHLAGER, Jaromír HUBÁLEK a René KIZEK. Electrochemical Study of Doxorubicin Interaction with Different Sequences of Double Stranded Oligonucleotides, Part II. International Journal of Electrochemical Science. 2012, roč. 7, č. 1, s. 34-49. ISSN 1452-3981.

@article{986085,
   author = {Hynek, David and Krejčová, Ludmila and Zítka, Ondřej and Adam, Vojtěch and Trnková, Libuše and Sochor, Jiří and Stiborová, Marie and Eckschlager, Tomáš and Hubálek, Jaromír and Kizek, René},
   article_number = {1},
   keywords = {intercalating drug; doxorubicin; hetero-nucleotides; square wave voltammetry; adsorptive transfer stripping technique; adriamycin; DNA},
   language = {eng},
   issn = {1452-3981},
   journal = {International Journal of Electrochemical Science},
   title = {Electrochemical Study of Doxorubicin Interaction with Different Sequences of Double Stranded Oligonucleotides, Part II},
   volume = {7},
   year = {2012}
}

TY  - JOUR
ID  - 986085
AU  - Hynek, David - Krejčová, Ludmila - Zítka, Ondřej - Adam, Vojtěch - Trnková, Libuše - Sochor, Jiří - Stiborová, Marie - Eckschlager, Tomáš - Hubálek, Jaromír - Kizek, René
PY  - 2012
TI  - Electrochemical Study of Doxorubicin Interaction with Different Sequences of Double Stranded Oligonucleotides, Part II
JF  - International Journal of Electrochemical Science
VL  - 7
IS  - 1
SP  - 34-49
EP  - 34-49
SN  - 14523981
KW  - intercalating drug
KW  - doxorubicin
KW  - hetero-nucleotides
KW  - square wave voltammetry
KW  - adsorptive transfer stripping technique
KW  - adriamycin
KW  - DNA
N2  - Interaction of low molecular weight compounds with DNA is one of general mechanisms utilized for an effective anticancer therapy. The anthracycline doxorubicin is one of the drugs that represent the compound with such effect. In our previous work [Hynek et al., Int. J. Electrochem, Sci. 7 (2012) xx] the electrochemical behaviour of doxorubicin interaction with single stranded ODN by using adsorptive transfer stripping square wave voltammetry was described. This paper is focused on the study of interaction of doxorubicin with double stranded ODNs (dsODNs) using the same technique. Here, we used four dsODNs possessing different primary structuresand observed the changes in their electrochemical behaviour after their treatment with three concentrations of doxorubicin for 5 hours. The changes found are discussed and differences in behaviours of individual dsODNs described and associated with their structure.
ER  -

HYNEK, David, Ludmila KREJČOVÁ, Ondřej ZÍTKA, Vojtěch ADAM, Libuše TRNKOVÁ, Jiří SOCHOR, Marie STIBOROVÁ, Tomáš ECKSCHLAGER, Jaromír HUBÁLEK a René KIZEK. Electrochemical Study of Doxorubicin Interaction with Different Sequences of Double Stranded Oligonucleotides, Part II. \textit{International Journal of Electrochemical Science}. 2012, roč.~7, č.~1, s.~34-49. ISSN~1452-3981.

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