MCP-1 AND RANTES CHEMOKINES AND FACTORS DESCRIBING RHEUMATOID ARTHRITIS

PÁVEK, Nikolas, Jolana LIPKOVÁ, Petr NĚMEC, Jindra GATTEROVA, Miroslav SOUČEK, Anna VAŠKŮ and Monika GOLDBERGOVÁ. MCP-1 AND RANTES CHEMOKINES AND FACTORS DESCRIBING RHEUMATOID ARTHRITIS. In 8th International Congress on Autoimmunity. 2012.

Basic information

• Original name: MCP-1 AND RANTES CHEMOKINES AND FACTORS DESCRIBING RHEUMATOID ARTHRITIS
• Name in Czech: Chemokiny MCP-1 a RANTES a faktory popisující revmatoidní artritidu
• Name (in English): MCP-1 AND RANTES CHEMOKINES AND FACTORS DESCRIBING RHEUMATOID ARTHRITIS
• Authors: PÁVEK, Nikolas, Jolana LIPKOVÁ, Petr NĚMEC, Jindra GATTEROVA, Miroslav SOUČEK, Anna VAŠKŮ and Monika GOLDBERGOVÁ.
• Edition: 8th International Congress on Autoimmunity, 2012.

Other information

• Type of outcome: Conference abstract
• Confidentiality degree: is not subject to a state or trade secret
• Keywords (in Czech): chemokiny, MCP-1, RANTES, IL-15, IL-10, revmatoidní artritida
• Keywords in English: chemokines, MCP-1,RANTES, IL-15, IL-10, rheumatoid arthritis
• Tags: International impact

Abstract

The MCP-1/CCL2 as well as RANTES/CCL5 chemokines are potent chemoattractant involved in immunoregulatory and inflammatory processes inclusive rheumatoid arthritis. In our study we found a significant increase in the prevalence of the heterozygous variant of the -855C/G MCP-1 polymorphism compared to homozygous variants in the IgM RF-positive subgroup of RA patients. Furthermore, an association of RANTES -403 G/A promoter polymorphism to circulating levels of IL15 and IL10 was found.

Abstract (in Czech)

Chemokiny MCP-1/CCL2 a RANTES/CCL5 jsou chemoatraktanty zapojené do imunoregulačních a zánětlivých procesů mimo jiné u revmatoidní artritidy. V naší studii jsme prokázali zvýšený výskyt heterozygotní varianty -855C/G MCP-1 ve srovnání s homozygotními variantami u IgM RF-pozitivní podskupiny pacientů s revmatoidní artritidou. Dále jsme prokázali asociaci polymorfismu -403 G/A u RANTES s hladinami IL15 a IL10 v cirkulaci.

Abstract (in English)

The MCP-1/CCL2 as well as RANTES/CCL5 chemokines are potent chemoattractant involved in immunoregulatory and inflammatory processes incisive rheumatoid arthritis. Inour study we found a significant increase in the prevalence of the heterozygous variant of the -855C/G MCP-1 polymorphism compared to homozygous variants in the IgM RF-positive subgroup of RA patients. Furthermore, an association of RANTES -403 G/A promoter polymorphism to circulating levels of IL15 and IL10 was found.

Links

• MUNI/A/0839/2011, interní kód MU: Name: Patofyziologické aspekty vybraných genotypů a fenotypů komplexních nemocí (Acronym: Patofyziologie komplexních nemocí)

Investor: Masaryk University, Category A