Detailed Information on Publication Record
2012
MCP-1 AND RANTES CHEMOKINES AND FACTORS DESCRIBING RHEUMATOID ARTHRITIS
PÁVEK, Nikolas, Jolana LIPKOVÁ, Petr NĚMEC, Jindra GATTEROVA, Miroslav SOUČEK et. al.Basic information
Original name
MCP-1 AND RANTES CHEMOKINES AND FACTORS DESCRIBING RHEUMATOID ARTHRITIS
Name in Czech
Chemokiny MCP-1 a RANTES a faktory popisující revmatoidní artritidu
Name (in English)
MCP-1 AND RANTES CHEMOKINES AND FACTORS DESCRIBING RHEUMATOID ARTHRITIS
Authors
PÁVEK, Nikolas, Jolana LIPKOVÁ, Petr NĚMEC, Jindra GATTEROVA, Miroslav SOUČEK, Anna VAŠKŮ and Monika GOLDBERGOVÁ
Edition
8th International Congress on Autoimmunity, 2012
Other information
Type of outcome
Konferenční abstrakt
Confidentiality degree
není předmětem státního či obchodního tajemství
Keywords (in Czech)
chemokiny, MCP-1, RANTES, IL-15, IL-10, revmatoidní artritida
Keywords in English
chemokines, MCP-1,RANTES, IL-15, IL-10, rheumatoid arthritis
Tags
International impact
Změněno: 25/3/2013 14:58, Ing. Mgr. Věra Pospíšilíková
V originále
The MCP-1/CCL2 as well as RANTES/CCL5 chemokines are potent chemoattractant involved in immunoregulatory and inflammatory processes inclusive rheumatoid arthritis. In our study we found a significant increase in the prevalence of the heterozygous variant of the -855C/G MCP-1 polymorphism compared to homozygous variants in the IgM RF-positive subgroup of RA patients. Furthermore, an association of RANTES -403 G/A promoter polymorphism to circulating levels of IL15 and IL10 was found.
In Czech
Chemokiny MCP-1/CCL2 a RANTES/CCL5 jsou chemoatraktanty zapojené do imunoregulačních a zánětlivých procesů mimo jiné u revmatoidní artritidy. V naší studii jsme prokázali zvýšený výskyt heterozygotní varianty -855C/G MCP-1 ve srovnání s homozygotními variantami u IgM RF-pozitivní podskupiny pacientů s revmatoidní artritidou. Dále jsme prokázali asociaci polymorfismu -403 G/A u RANTES s hladinami IL15 a IL10 v cirkulaci.
In English
The MCP-1/CCL2 as well as RANTES/CCL5 chemokines are potent chemoattractant involved in immunoregulatory and inflammatory processes incisive rheumatoid arthritis. Inour study we found a significant increase in the prevalence of the heterozygous variant of the -855C/G MCP-1 polymorphism compared to homozygous variants in the IgM RF-positive subgroup of RA patients. Furthermore, an association of RANTES -403 G/A promoter polymorphism to circulating levels of IL15 and IL10 was found.
Links
| MUNI/A/0839/2011, interní kód MU |
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