Matrix metalloproteinase 13 genotype in rs640198 polymorphism
is associated with severe coronary artery disease

J 2012

Matrix metalloproteinase 13 genotype in rs640198 polymorphism is associated with severe coronary artery disease

VAŠKŮ, Anna, Jaroslav MELUZÍN, Jiří BLAHÁK, Vladimír KINCL, Monika PÁVKOVÁ GOLDBERGOVÁ et. al.

Základní údaje

Originální název

Matrix metalloproteinase 13 genotype in rs640198 polymorphism is associated with severe coronary artery disease

Autoři

VAŠKŮ, Anna (203 Česká republika, garant, domácí), Jaroslav MELUZÍN (203 Česká republika, domácí), Jiří BLAHÁK (203 Česká republika, domácí), Vladimír KINCL (203 Česká republika, domácí), Monika PÁVKOVÁ GOLDBERGOVÁ (203 Česká republika, domácí), Jan SITAR (203 Česká republika, domácí), Filip ZLÁMAL (203 Česká republika, domácí), Julie BIENERTOVÁ VAŠKŮ (203 Česká republika, domácí) a Jiří VÍTOVEC (203 Česká republika, domácí)

Vydání

DISEASE MARKERS, AMSTERDAM, IOS PRESS, 2012, 0278-0240

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10600 1.6 Biological sciences

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.140

Kód RIV

RIV/00216224:14110/12:00064861

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.3233/DMA-2012-0902

UT WoS

000305391200005

Klíčová slova anglicky

MMP-13; CAD; rs640198; severity

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 4. 2. 2013 10:33, Mgr. Michal Petr

Anotace

V originále

Atherosclerosis as a main etiopathogenetic source for coronary artery disease (CAD) development is intimately related to dynamic changes in the extracellular matrix (ECM). Elevated levels of MMP-13 have been observed in human atherosclerotic plaques which could also involve variability in MMP-13 gene. The aim of the study was to associate rs640198 polymorphism with CAD and/or with its severity. The study comprised 1071 consecutive patients with suspected or known coronary artery disease (CAD), confirmed by coronary angiography. Genotyping for the rs640198 polymorphism in MMP-13 gene was performed using Taqman (R) assay. The TT and TG genotypes of rs640198 polymorphism in MMP-13 gene confer the significantly increased risk of triple vessel disease compared to patients without atherosclerotic lesions in coronary arteries (odds ratio = 1.64, Pcorr = 0.05). Furthermore, an increased risk of having 5 and more stenoses (odds ratio = 1.90, Pcorr = 0.004) was observed in TT and TG carriers (sensitivity of 0.613 and a specificity of 0.544; power of the test is 0.87). The T allele of MMP-13 intron polymorphism rs640198 is associated with the severity of coronary artery disease, represented by the number of affected arteries as well as by the number of stenoses confirmed by coronarography.

Návaznosti

NS10206, projekt VaV

Název: Asociace polymorfismů v genech pro metaloproteinázy, jejich inhibitory, ACE a ACE2 s centrálním pulsním tlakem u kardiovaskulárních pacientů

Investor: Ministerstvo zdravotnictví ČR, Asociace polymorfismů v genech pro metaloproteinázy, jejich inhibitory, ACE, ACE2 a apelinu s centrálním pulsním tlakem u pacientů s ischemickou chorobou srdeční

Citovat

VAŠKŮ, Anna, Jaroslav MELUZÍN, Jiří BLAHÁK, Vladimír KINCL, Monika PÁVKOVÁ GOLDBERGOVÁ, Jan SITAR, Filip ZLÁMAL, Julie BIENERTOVÁ VAŠKŮ a Jiří VÍTOVEC. Matrix metalloproteinase 13 genotype in rs640198 polymorphism is associated with severe coronary artery disease. DISEASE MARKERS. AMSTERDAM: IOS PRESS, 2012, roč. 33, č. 1, s. 43-49. ISSN 0278-0240. Dostupné z: https://dx.doi.org/10.3233/DMA-2012-0902.

@article{987363,
   author = {Vašků, Anna and Meluzín, Jaroslav and Blahák, Jiří and Kincl, Vladimír and Pávková Goldbergová, Monika and Sitar, Jan and Zlámal, Filip and Bienertová Vašků, Julie and Vítovec, Jiří},
   article_location = {AMSTERDAM},
   article_number = {1},
   doi = {http://dx.doi.org/10.3233/DMA-2012-0902},
   keywords = {MMP-13; CAD; rs640198; severity},
   language = {eng},
   issn = {0278-0240},
   journal = {DISEASE MARKERS},
   title = {Matrix metalloproteinase 13 genotype in rs640198 polymorphism is associated with severe coronary artery disease},
   volume = {33},
   year = {2012}
}

TY  - JOUR
ID  - 987363
AU  - Vašků, Anna - Meluzín, Jaroslav - Blahák, Jiří - Kincl, Vladimír - Pávková Goldbergová, Monika - Sitar, Jan - Zlámal, Filip - Bienertová Vašků, Julie - Vítovec, Jiří
PY  - 2012
TI  - Matrix metalloproteinase 13 genotype in rs640198 polymorphism is associated with severe coronary artery disease
JF  - DISEASE MARKERS
VL  - 33
IS  - 1
SP  - 43-49
EP  - 43-49
PB  - IOS PRESS
SN  - 02780240
KW  - MMP-13
KW  - CAD
KW  - rs640198
KW  - severity
N2  - Atherosclerosis as a main etiopathogenetic source for coronary artery disease (CAD) development is intimately related to dynamic changes in the extracellular matrix (ECM). Elevated levels of MMP-13 have been observed in human atherosclerotic plaques which could also involve variability in MMP-13 gene. The aim of the study was to associate rs640198 polymorphism with CAD and/or with its severity. The study comprised 1071 consecutive patients with suspected or known coronary artery disease (CAD), confirmed by coronary angiography. Genotyping for the rs640198 polymorphism in MMP-13 gene was performed using Taqman (R) assay. The TT and TG genotypes of rs640198 polymorphism in MMP-13 gene confer the significantly increased risk of triple vessel disease compared to patients without atherosclerotic lesions in coronary arteries (odds ratio = 1.64, Pcorr = 0.05). Furthermore, an increased risk of having 5 and more stenoses (odds ratio = 1.90, Pcorr = 0.004) was observed in TT and TG carriers (sensitivity of 0.613 and a specificity of 0.544; power of the test is 0.87). The T allele of MMP-13 intron polymorphism rs640198 is associated with the severity of coronary artery disease, represented by the number of affected arteries as well as by the number of stenoses confirmed by coronarography.
ER  -

VAŠKŮ, Anna, Jaroslav MELUZÍN, Jiří BLAHÁK, Vladimír KINCL, Monika PÁVKOVÁ GOLDBERGOVÁ, Jan SITAR, Filip ZLÁMAL, Julie BIENERTOVÁ VAŠKŮ a Jiří VÍTOVEC. Matrix metalloproteinase 13 genotype in rs640198 polymorphism is associated with severe coronary artery disease. \textit{DISEASE MARKERS}. AMSTERDAM: IOS PRESS, 2012, roč.~33, č.~1, s.~43-49. ISSN~0278-0240. Dostupné z: https://dx.doi.org/10.3233/DMA-2012-0902.

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