Variability in CNR1 locus influences protein intake and smoking
status in the Central-European population

J 2012

Variability in CNR1 locus influences protein intake and smoking status in the Central-European population

BIENERTOVÁ VAŠKŮ, Julie, Petr BIENERT, Lenka SLOVÁČKOVÁ, Lenka SÁBLÍKOVÁ, Zlata PISKÁČKOVÁ et. al.

Základní údaje

Originální název

Variability in CNR1 locus influences protein intake and smoking status in the Central-European population

Autoři

BIENERTOVÁ VAŠKŮ, Julie (203 Česká republika, garant, domácí), Petr BIENERT (203 Česká republika, domácí), Lenka SLOVÁČKOVÁ (203 Česká republika, domácí), Lenka SÁBLÍKOVÁ (203 Česká republika, domácí), Zlata PISKÁČKOVÁ (203 Česká republika, domácí), Martin FOREJT (203 Česká republika, domácí), Zbyněk ŠPLÍCHAL (203 Česká republika, domácí), Filip ZLÁMAL (203 Česká republika, domácí) a Anna VAŠKŮ (203 Česká republika, domácí)

Vydání

Nutritional Neuroscience, Anglie, W. S. Maney and Son, Ltd, 2012, 1028-415X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 1.647

Kód RIV

RIV/00216224:14110/12:00060422

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1179/1476830512Y.0000000001

UT WoS

000306436000002

Klíčová slova anglicky

Endocannabinoids; SNP; Dietary composition; Macronutrients; Gene

Příznaky

Mezinárodní význam

Změněno: 20. 8. 2012 11:43, Mgr. Michal Petr

Anotace

V originále

Objectives: The endocannabinoid receptor 1 (CB1) is encoded by the CNR1 gene and has been recently recognized to play an important role in the regulation of satiety and feeding behaviour with a huge potential of modulating metabolic response and feeding control. The aim of the study was to investigate the potential of three selected single nucleotide polymorphisms (SNPs) in the CNR1 locus on native dietary composition in the Central-European Caucasian population. Methods: A total of 258 unrelated individuals originating from the Central-European Caucasian population were enrolled into the study and rs1049353, rs12720071, and rs806368 polymorphisms in CNR1 locus were examined in these individuals using PCR-based methodology. Body composition was assessed using a bioimpedance method, various anthropometric parameters were investigated (waist and hip circumference, skin folds), and native dietary composition was analysed using 7-day food records as well as a food frequency questionnaire. Results: Allelic variations and common haplotypes in the CNR1 gene were associated with the daily intake of proteins, fluids, and fibre, regardless of the physical activity of the individuals. The common haplotype in the CNR1 gene was associated with self-reported smoking (number of cigarettes per day, smoking years). Discussion: Our results indicate that specific genetic variations in the CNR1 gene may act as susceptibility markers for specific dietary composition in the Central-European population.

Přiložené soubory

NNS-15-4-97.pdf

Požádat o autorskou verzi souboru

Citovat

BIENERTOVÁ VAŠKŮ, Julie, Petr BIENERT, Lenka SLOVÁČKOVÁ, Lenka SÁBLÍKOVÁ, Zlata PISKÁČKOVÁ, Martin FOREJT, Zbyněk ŠPLÍCHAL, Filip ZLÁMAL a Anna VAŠKŮ. Variability in CNR1 locus influences protein intake and smoking status in the Central-European population. Nutritional Neuroscience. Anglie: W. S. Maney and Son, Ltd, 2012, roč. 15, č. 4, s. 163-170. ISSN 1028-415X. Dostupné z: https://dx.doi.org/10.1179/1476830512Y.0000000001.

@article{987364,
   author = {Bienertová Vašků, Julie and Bienert, Petr and Slováčková, Lenka and Sáblíková, Lenka and Piskáčková, Zlata and Forejt, Martin and Šplíchal, Zbyněk and Zlámal, Filip and Vašků, Anna},
   article_location = {Anglie},
   article_number = {4},
   doi = {http://dx.doi.org/10.1179/1476830512Y.0000000001},
   keywords = {Endocannabinoids; SNP; Dietary composition; Macronutrients; Gene},
   language = {eng},
   issn = {1028-415X},
   journal = {Nutritional Neuroscience},
   title = {Variability in CNR1 locus influences protein intake and smoking status in the Central-European population},
   volume = {15},
   year = {2012}
}

TY  - JOUR
ID  - 987364
AU  - Bienertová Vašků, Julie - Bienert, Petr - Slováčková, Lenka - Sáblíková, Lenka - Piskáčková, Zlata - Forejt, Martin - Šplíchal, Zbyněk - Zlámal, Filip - Vašků, Anna
PY  - 2012
TI  - Variability in CNR1 locus influences protein intake and smoking status in the Central-European population
JF  - Nutritional Neuroscience
VL  - 15
IS  - 4
SP  - 163-170
EP  - 163-170
PB  - W. S. Maney and Son, Ltd
SN  - 1028415X
KW  - Endocannabinoids
KW  - SNP
KW  - Dietary composition
KW  - Macronutrients
KW  - Gene
N2  - Objectives: The endocannabinoid receptor 1 (CB1) is encoded by the CNR1 gene and has been recently recognized to play an important role in the regulation of satiety and feeding behaviour with a huge potential of modulating metabolic response and feeding control. The aim of the study was to investigate the potential of three selected single nucleotide polymorphisms (SNPs) in the CNR1 locus on native dietary composition in the Central-European Caucasian population. Methods: A total of 258 unrelated individuals originating from the Central-European Caucasian population were enrolled into the study and rs1049353, rs12720071, and rs806368 polymorphisms in CNR1 locus were examined in these individuals using PCR-based methodology. Body composition was assessed using a bioimpedance method, various anthropometric parameters were investigated (waist and hip circumference, skin folds), and native dietary composition was analysed using 7-day food records as well as a food frequency questionnaire. Results: Allelic variations and common haplotypes in the CNR1 gene were associated with the daily intake of proteins, fluids, and fibre, regardless of the physical activity of the individuals. The common haplotype in the CNR1 gene was associated with self-reported smoking (number of cigarettes per day, smoking years). Discussion: Our results indicate that specific genetic variations in the CNR1 gene may act as susceptibility markers for specific dietary composition in the Central-European population.
ER  -

BIENERTOVÁ VAŠKŮ, Julie, Petr BIENERT, Lenka SLOVÁČKOVÁ, Lenka SÁBLÍKOVÁ, Zlata PISKÁČKOVÁ, Martin FOREJT, Zbyněk ŠPLÍCHAL, Filip ZLÁMAL a Anna VAŠKŮ. Variability in CNR1 locus influences protein intake and smoking status in the Central-European population. \textit{Nutritional Neuroscience}. Anglie: W. S. Maney and Son, Ltd, 2012, roč.~15, č.~4, s.~163-170. ISSN~1028-415X. Dostupné z: https://dx.doi.org/10.1179/1476830512Y.0000000001.

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