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@inbook{987445, author = {Doubek, Michael and Mayer, Jiří}, address = {New York}, booktitle = {Acute Lymphoblastic Leukemia: Etiology, Pathogenesis and Treatments}, editor = {Severo Vecchione, Luigi Tedesco}, keywords = {acute lymphoblastic leukemia; therapy; maintenance}, howpublished = {tištěná verze "print"}, language = {eng}, location = {New York}, isbn = {978-1-61470-872-8}, pages = {197-204}, publisher = {Nova Science Publishers}, title = {Maintenance therapy in Ph negative adult acute lymphoblastic leukemia}, year = {2011} }
TY - CHAP ID - 987445 AU - Doubek, Michael - Mayer, Jiří PY - 2011 TI - Maintenance therapy in Ph negative adult acute lymphoblastic leukemia VL - Cancer Etiology, Diagnosis and Treatments PB - Nova Science Publishers CY - New York SN - 9781614708728 KW - acute lymphoblastic leukemia KW - therapy KW - maintenance N2 - Maintenance therapy means long-term administration of low-dose chemotherapy or other drugs. With the exception of patients with mature B-cell acute lymphoblastic leukemia (ALL), long-term maintenance therapy, adapted from its successful use in pediatric ALL, is generally given in adult ALL for one to three years, with a backbone of daily 6-mercaptopurine (MP) and weekly methothrexate (MTX). In the chapter we discuss the role of maintenance in adult ALL, the role of intensification of maintenance, maintenance after autologous stem cell transplantation and the role of minimal residual disease evaluation during maintenance. ER -
DOUBEK, Michael a Jiří MAYER. Maintenance therapy in Ph negative adult acute lymphoblastic leukemia. In Severo Vecchione, Luigi Tedesco. \textit{Acute Lymphoblastic Leukemia: Etiology, Pathogenesis and Treatments}. New York: Nova Science Publishers, 2011, s.~197-204. Cancer Etiology, Diagnosis and Treatments. ISBN~978-1-61470-872-8.
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