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@article{987487, author = {Drozina, Gorazd and Kohoutek, Jiří and Nishiya, Tadashi and Peterlin, B Matija}, article_location = {Bethesda, USA}, article_number = {52}, doi = {http://dx.doi.org/10.1074/jbc.M608538200}, keywords = {ELONGATION-FACTOR-B; UBIQUITIN-MEDIATED PROTEOLYSIS; HUMAN-IMMUNODEFICIENCY-VIRUS; CREB BINDING-PROTEIN; TOLL-LIKE RECEPTORS; ACTIVATE TRANSCRIPTION; DIFFERENTIAL USAGE; DENDRITIC CELLS; CIITA FUNCTION; IFN-GAMMA}, language = {eng}, issn = {0021-9258}, journal = {Journal of Biological Chemistry}, title = {Sequential modifications in class II transactivator isoform 1 induced by lipopolysaccharide stimulate major histocompatibility complex class II transcription in macrophages}, url = {http://www.jbc.org/content/early/2006/11/09/jbc.M608538200.full.pdf+html}, volume = {281}, year = {2006} }
TY - JOUR ID - 987487 AU - Drozina, Gorazd - Kohoutek, Jiří - Nishiya, Tadashi - Peterlin, B Matija PY - 2006 TI - Sequential modifications in class II transactivator isoform 1 induced by lipopolysaccharide stimulate major histocompatibility complex class II transcription in macrophages JF - Journal of Biological Chemistry VL - 281 IS - 52 SP - 39963-39970 EP - 39963-39970 PB - Amer. Soc. Biochem. Mol. Biol. SN - 00219258 KW - ELONGATION-FACTOR-B KW - UBIQUITIN-MEDIATED PROTEOLYSIS KW - HUMAN-IMMUNODEFICIENCY-VIRUS KW - CREB BINDING-PROTEIN KW - TOLL-LIKE RECEPTORS KW - ACTIVATE TRANSCRIPTION KW - DIFFERENTIAL USAGE KW - DENDRITIC CELLS KW - CIITA FUNCTION KW - IFN-GAMMA UR - http://www.jbc.org/content/early/2006/11/09/jbc.M608538200.full.pdf+html N2 - By presenting antigenic peptides on major histocompatibility complex class (MHC) II determinants to CD4(+) T cells, macrophages help to direct the establishment of adaptive immunity. We found that in these cells, lipopolysaccharide stimulates the expression of MHC II genes via the activation of Erk1/2, which is mediated by Toll-like receptor 4. Erk1/2 then phosphorylates the serine at position 357, which is located in a degron of CIITA isoform 1 that leads to its monoubiquitylation. Thus modified, CIITA isoform 1 binds P-TEFb, which mediates the elongation of RNA polymerase II and co-transcriptional processing of nascent transcripts. This induction leads to the expression of MHC II genes. Subsequent polyubiquitylation results in the degradation of CIITA isoform 1. Thus, the signaling cascade from Toll-like receptor 4 to CIITA isoform 1 represents one connection between innate and adaptive immunity in macrophages. ER -
DROZINA, Gorazd, Jiří KOHOUTEK, Tadashi NISHIYA a B Matija PETERLIN. Sequential modifications in class II transactivator isoform 1 induced by lipopolysaccharide stimulate major histocompatibility complex class II transcription in macrophages. \textit{Journal of Biological Chemistry}. Bethesda, USA: Amer. Soc. Biochem. Mol. Biol., 2006, roč.~281, č.~52, s.~39963-39970. ISSN~0021-9258. Dostupné z: https://dx.doi.org/10.1074/jbc.M608538200.
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