Cognitive effects of long-term treatment with waking-hour
subcutaneous apomorphine infusions in patients with advanced
Parkinson's disease

J 2011

Cognitive effects of long-term treatment with waking-hour subcutaneous apomorphine infusions in patients with advanced Parkinson's disease

KUBÍKOVÁ, Radka, Mojmír TYRLÍK a Irena REKTOROVÁ

Základní údaje

Originální název

Cognitive effects of long-term treatment with waking-hour subcutaneous apomorphine infusions in patients with advanced Parkinson's disease

Autoři

KUBÍKOVÁ, Radka (203 Česká republika, domácí), Mojmír TYRLÍK (203 Česká republika, domácí) a Irena REKTOROVÁ (203 Česká republika, garant, domácí)

Vydání

Ceska a Slovenska Neurologie a Neurochirurgie, Czech Medical Association J.E. Purkyne, 2011, 1210-7859

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 0.279

Kód RIV

RIV/00216224:14740/11:00060542

Organizační jednotka

Středoevropský technologický institut

UT WoS

000294035900009

Klíčová slova anglicky

Affective; Apomorphine; Cognitive; Dementia; Parkinson's disease

Štítky

ok, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 23. 4. 2013 07:30, Olga Křížová

Anotace

V originále

Aims: To determine whether long-term treatment with continuous subcutaneous apomorphine infusions (CSAI) is safe for patients with Parkinson's disease (PD) with a history of hallucinations and/or marked cognitive deficit. Methods: 12 PD patients (9 men, 3 women; age 71.8 +- 6 years) were given neuropsychological assessment prior to continuous administration of CSAI and fourteen months after it. Results: CSAI led to clinical improvement, at least minimal, in all subjects. However, the treatment led to statistically significant impairment in verbal fluency tasks, the Mattis dementia rating scale (MDRS) score and the attention and initiation subtests. No mood changes were detected. Conclusions: We observed significant impairment in "frontal-like" tasks after continuous treatment with CSAI in our PD patients with baseline cognitive impairment. Further longitudinal controlled studies are needed to assess the impact of both CSAI and PD progression. We suggest cautious selection of patients eligible for CSAI therapy with respect to their cognitive profiles and/or neuropsychiatric complications.

Návaznosti

ED1.1.00/02.0068, projekt VaV

Název: CEITEC - central european institute of technology

MSM0021622404, záměr

Název: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Přiložené soubory

Rektorova_CSNN_2011-ApoGo.pdf

Požádat o autorskou verzi souboru

Citovat

KUBÍKOVÁ, Radka, Mojmír TYRLÍK a Irena REKTOROVÁ. Cognitive effects of long-term treatment with waking-hour subcutaneous apomorphine infusions in patients with advanced Parkinson's disease. Ceska a Slovenska Neurologie a Neurochirurgie. Czech Medical Association J.E. Purkyne, 2011, roč. 74, č. 4, s. 463-466. ISSN 1210-7859.

@article{988744,
   author = {Kubíková, Radka and Tyrlík, Mojmír and Rektorová, Irena},
   article_number = {4},
   keywords = {Affective; Apomorphine; Cognitive; Dementia; Parkinson's disease},
   language = {eng},
   issn = {1210-7859},
   journal = {Ceska a Slovenska Neurologie a Neurochirurgie},
   title = {Cognitive effects of long-term treatment with waking-hour subcutaneous apomorphine infusions in patients with advanced Parkinson's disease},
   url = {http://www.csnn.eu/en/czech-slovak-neurology-article/cognitive-effects-of-long-term-treatment-with-waking-hour-subcutaneous-apomorphine-infusions-in-patients-with-adv-35795?confirm_rules=1},
   volume = {74},
   year = {2011}
}

TY  - JOUR
ID  - 988744
AU  - Kubíková, Radka - Tyrlík, Mojmír - Rektorová, Irena
PY  - 2011
TI  - Cognitive effects of long-term treatment with waking-hour subcutaneous apomorphine infusions in patients with advanced Parkinson's disease
JF  - Ceska a Slovenska Neurologie a Neurochirurgie
VL  - 74
IS  - 4
SP  - 463-466
EP  - 463-466
PB  - Czech Medical Association J.E. Purkyne
SN  - 12107859
KW  - Affective
KW  - Apomorphine
KW  - Cognitive
KW  - Dementia
KW  - Parkinson's disease
UR  - http://www.csnn.eu/en/czech-slovak-neurology-article/cognitive-effects-of-long-term-treatment-with-waking-hour-subcutaneous-apomorphine-infusions-in-patients-with-adv-35795?confirm_rules=1
L2  - http://www.csnn.eu/en/czech-slovak-neurology-article/cognitive-effects-of-long-term-treatment-with-waking-hour-subcutaneous-apomorphine-infusions-in-patients-with-adv-35795?confirm_rules=1
N2  - Aims: To determine whether long-term treatment with continuous subcutaneous apomorphine infusions (CSAI) is safe for patients with Parkinson's disease (PD) with a history of hallucinations and/or marked cognitive deficit. Methods: 12 PD patients (9 men, 3 women; age 71.8 +- 6 years) were given neuropsychological assessment prior to continuous administration of CSAI and fourteen months after it. Results: CSAI led to clinical improvement, at least minimal, in all subjects. However, the treatment led to statistically significant impairment in verbal fluency tasks, the Mattis dementia rating scale (MDRS) score and the attention and initiation subtests. No mood changes were detected. Conclusions: We observed significant impairment in "frontal-like" tasks after continuous treatment with CSAI in our PD patients with baseline cognitive impairment. Further longitudinal controlled studies are needed to assess the impact of both CSAI and PD progression. We suggest cautious selection of patients eligible for CSAI therapy with respect to their cognitive profiles and/or neuropsychiatric complications.
ER  -

KUBÍKOVÁ, Radka, Mojmír TYRLÍK a Irena REKTOROVÁ. Cognitive effects of long-term treatment with waking-hour subcutaneous apomorphine infusions in patients with advanced Parkinson's disease. \textit{Ceska a Slovenska Neurologie a Neurochirurgie}. Czech Medical Association J.E. Purkyne, 2011, roč.~74, č.~4, s.~463-466. ISSN~1210-7859.

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