| ANGHEL, Silvia I., Rafael CORREA-ROCHAL, Eva BUDINSKÁ, Kayluz F. BOLIGANL, Shahnaz ABRAHAM, Sara COLOMBETTI, Lionel FONTAO, Agnese MARIOTTI, Donata RIMOLDI, Ghanem E. GHANEM, David E. FISHER, Frederic LÉVY, Mauro DELORENZI a Vincent PIGUET. Breast cancer suppressor candidate-1 (BCSC-1) is a melanoma tumor suppressor that down regulates MITF. Pigment Cell & Melanoma Research. HOBOKEN: WILEY-BLACKWELL, 2012, roč. 25, č. 4, s. 482-487. ISSN 1755-1471. Dostupné z: https://dx.doi.org/10.1111/j.1755-148X.2012.01018.x. |
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@article{989194,
author = {Anghel, Silvia I. and CorreaandRochal, Rafael and Budinská, Eva and Boliganl, Kayluz F. and Abraham, Shahnaz and Colombetti, Sara and Fontao, Lionel and Mariotti, Agnese and Rimoldi, Donata and Ghanem, Ghanem E. and Fisher, David E. and Lévy, Frederic and Delorenzi, Mauro and Piguet, Vincent},
article_location = {HOBOKEN},
article_number = {4},
doi = {http://dx.doi.org/10.1111/j.1755-148X.2012.01018.x},
keywords = {human; melanoma; potential biomarker; BCSC-1; tumor suppressor; MITF; proliferation},
language = {eng},
issn = {1755-1471},
journal = {Pigment Cell & Melanoma Research},
title = {Breast cancer suppressor candidate-1 (BCSC-1) is a melanoma tumor suppressor that down regulates MITF},
volume = {25},
year = {2012}
}
TY - JOUR
ID - 989194
AU - Anghel, Silvia I. - Correa-Rochal, Rafael - Budinská, Eva - Boliganl, Kayluz F. - Abraham, Shahnaz - Colombetti, Sara - Fontao, Lionel - Mariotti, Agnese - Rimoldi, Donata - Ghanem, Ghanem E. - Fisher, David E. - Lévy, Frederic - Delorenzi, Mauro - Piguet, Vincent
PY - 2012
TI - Breast cancer suppressor candidate-1 (BCSC-1) is a melanoma tumor suppressor that down regulates MITF
JF - Pigment Cell & Melanoma Research
VL - 25
IS - 4
SP - 482-487
EP - 482-487
PB - WILEY-BLACKWELL
SN - 17551471
KW - human
KW - melanoma
KW - potential biomarker
KW - BCSC-1
KW - tumor suppressor
KW - MITF
KW - proliferation
N2 - Understanding the molecular aberrations involved in the development and progression of metastatic melanoma (MM) is essential for a better diagnosis and targeted therapy. We identified breast cancer suppressor candidate-1 (BCSC-1) as a novel tumor suppressor in melanoma. BCSC-1 expression is decreased in human MM, and its ectopic expression in MMderived cell lines blocks tumor formation in vivo and melanoma cell proliferation in vitro while increasing cell migration. We demonstrate that BCSC-1 binds to Sox10, which down regulates MITF, and results in a switch of melanoma cells from a proliferative to a migratory phenotype. In conclusion, we have identified BCSC-1 as a tumor suppressor in melanoma and as a novel regulator of the MITF pathway.
ER -
ANGHEL, Silvia I., Rafael CORREA-ROCHAL, Eva BUDINSKÁ, Kayluz F. BOLIGANL, Shahnaz ABRAHAM, Sara COLOMBETTI, Lionel FONTAO, Agnese MARIOTTI, Donata RIMOLDI, Ghanem E. GHANEM, David E. FISHER, Frederic LÉVY, Mauro DELORENZI a Vincent PIGUET. Breast cancer suppressor candidate-1 (BCSC-1) is a melanoma tumor suppressor that down regulates MITF. \textit{Pigment Cell \&{} Melanoma Research}. HOBOKEN: WILEY-BLACKWELL, 2012, roč.~25, č.~4, s.~482-487. ISSN~1755-1471. Dostupné z: https://dx.doi.org/10.1111/j.1755-148X.2012.01018.x.
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