Investigation into the concentration of serum pre-albumin nad
trace elements to monitor the nutritional status of
phenylketonuric and hyperphenylalninemic patients

a 2012

Investigation into the concentration of serum pre-albumin nad trace elements to monitor the nutritional status of phenylketonuric and hyperphenylalninemic patients

PROCHÁZKOVÁ, Dagmar, Lucie KOLBOVÁ, Jiří JARKOVSKÝ, Hana VINOHRADSKÁ, Petra KONEČNÁ et. al.

Základní údaje

Originální název

Investigation into the concentration of serum pre-albumin nad trace elements to monitor the nutritional status of phenylketonuric and hyperphenylalninemic patients

Název česky

vyšetření prealbuminu a stopových prvků v séru u pacientů s PKU a HPA ke sledování jejich nutričního stavu

Autoři

PROCHÁZKOVÁ, Dagmar, Lucie KOLBOVÁ, Jiří JARKOVSKÝ, Hana VINOHRADSKÁ, Petra KONEČNÁ a Zdeněk DOLEŽEL

Vydání

J Inherit Metab Dis 35, 2012,Suppl1, S 44, 2012

Další údaje

Jazyk

angličtina

Typ výsledku

Konferenční abstrakt

Obor

30209 Paediatrics

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 4.070

Organizační jednotka

Lékařská fakulta

ISSN

UT WoS

000307513100146

Klíčová slova česky

PKU HPA prealbumin stopové prvky

Klíčová slova anglicky

PKU HPA pre-albumin trace elements

Změněno: 8. 1. 2013 10:35, doc. MUDr. Dagmar Procházková, Ph.D.

Anotace

V originále

Aim: Phenylketonuria is an inherited disorder of metabolism of the amino acid phenylalanine caused by a deficit of the enzyme phenylalaninhydroxylase. It is treated with a low-protein diet containing a low content of phenylalanine to prevent mental affection of the patient. The objective of the present study was to assess the compliance of our phenylketonuric (PKU) and hyperphenylalaninemic (HPA) patients; to determine the concentration of serum pre-albumin, selenium, zinc and iron to discover the potential correlation between the amount of proteins in food and their metabolic control. Methods: We studied 174 patients of which 113 were children (age 1-18), 60 with PKU and 53 with HPA and 61 were adults (age 18-42), 51 with PKU and 10 with HPA. Results: We did not prove a statistically significant difference in the concentration of serum pre-albumin, zinc and iron among the respective groups. We approved statistically significant difference in serum selenium concentrations of adult PKU and HPA patients (p=0.006; Mann-Whitney U test). Conclusions: The concentration of serum selenium could be used as indirect marker in evaluation of the risk of late complications of dietary therapy.

Citovat

PROCHÁZKOVÁ, Dagmar, Lucie KOLBOVÁ, Jiří JARKOVSKÝ, Hana VINOHRADSKÁ, Petra KONEČNÁ a Zdeněk DOLEŽEL. Investigation into the concentration of serum pre-albumin nad trace elements to monitor the nutritional status of phenylketonuric and hyperphenylalninemic patients. In J Inherit Metab Dis 35, 2012,Suppl1, S 44. 2012. ISSN 0141-8955.

@proceedings{989618,
   author = {Procházková, Dagmar and Kolbová, Lucie and Jarkovský, Jiří and Vinohradská, Hana and Konečná, Petra and Doležel, Zdeněk},
   booktitle = {J Inherit Metab Dis 35, 2012,Suppl1, S 44},
   keywords = {PKU HPA pre-albumin trace elements},
   language = {eng},
   title = {Investigation into the concentration of serum pre-albumin nad trace elements to monitor the nutritional status of phenylketonuric and hyperphenylalninemic patients},
   year = {2012}
}

TY  - CONF
ID  - 989618
AU  - Procházková, Dagmar - Kolbová, Lucie - Jarkovský, Jiří - Vinohradská, Hana - Konečná, Petra - Doležel, Zdeněk
PY  - 2012
TI  - Investigation into the concentration of serum pre-albumin nad trace elements to monitor the nutritional status of phenylketonuric and hyperphenylalninemic patients
KW  - PKU HPA pre-albumin trace elements
N2  - Aim: Phenylketonuria is an inherited disorder of metabolism of the amino acid phenylalanine caused by a deficit of the enzyme phenylalaninhydroxylase. It is treated with a low-protein diet containing a low content of phenylalanine to prevent mental affection of the patient. The objective of the present study was to assess the compliance of our phenylketonuric (PKU) and hyperphenylalaninemic (HPA) patients; to determine the concentration of serum pre-albumin, selenium, zinc and iron to discover the potential correlation between the amount of proteins in food and their metabolic control. Methods: We studied 174 patients of which 113 were children (age 1-18), 60 with PKU and 53 with HPA and 61 were adults (age 18-42), 51 with PKU and 10 with HPA. Results: We did not prove a statistically significant difference in the concentration of serum pre-albumin, zinc and iron among the respective groups. We approved statistically significant difference in serum selenium concentrations of adult PKU and HPA patients (p=0.006; Mann-Whitney U test). Conclusions: The concentration of serum selenium could be used as indirect marker in evaluation of the risk of late complications of dietary therapy.
ER  -

PROCHÁZKOVÁ, Dagmar, Lucie KOLBOVÁ, Jiří JARKOVSKÝ, Hana VINOHRADSKÁ, Petra KONEČNÁ a Zdeněk DOLEŽEL. Investigation into the concentration of serum pre-albumin nad trace elements to monitor the nutritional status of phenylketonuric and hyperphenylalninemic patients. In \textit{J Inherit Metab Dis 35, 2012,Suppl1, S 44}. 2012. ISSN~0141-8955.

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