Developmental silencing of the AtTERT gene is associated with
increased H3K27me3 loading and maintenance of its euchromatic
environment

J 2012

Developmental silencing of the AtTERT gene is associated with increased H3K27me3 loading and maintenance of its euchromatic environment

OGROCKÁ, Anna, Eva SÝKOROVÁ, Jiří FAJKUS a Miloslava FOJTOVÁ

Základní údaje

Originální název

Developmental silencing of the AtTERT gene is associated with increased H3K27me3 loading and maintenance of its euchromatic environment

Autoři

OGROCKÁ, Anna (203 Česká republika, domácí), Eva SÝKOROVÁ (203 Česká republika, domácí), Jiří FAJKUS (203 Česká republika, domácí) a Miloslava FOJTOVÁ (203 Česká republika, garant, domácí)

Vydání

Journal of Experimental Botany, Oxford, OXFORD UNIV PRESS, 2012, 0022-0957

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

Genetika a molekulární biologie

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 5.242

Kód RIV

RIV/00216224:14740/12:00057105

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.1093/jxb/ers107

UT WoS

000306686900021

Klíčová slova anglicky

Arabidopsis thaliana; developmental regulation; DNA methylation; histone modifications; telomerase

Štítky

ok, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 18. 1. 2017 09:10, prof. RNDr. Jiří Fajkus, CSc.

Anotace

V originále

elomerase is precisely regulated during development and in animals, involvement of the epigenetic mechanisms to the regulation of the telomerase reverse transcriptase (TERT) gene transcription was reported. In Arabidopsis thaliana model plant, low level of methylated cytosines in the TERT upstream region was detected in both telomerase-positive and telomerase-negative tissues and AtTERT chromatin maintained the euchromatic nature despite the increased H3K27me3 loading in telomerase-negative tissue. These results may reflect a unique attribute of plants – their totipotency - which accords with a reversible and dynamic character of telomerase silencing.

Návaznosti

ED1.1.00/02.0068, projekt VaV

Název: CEITEC - central european institute of technology

GAP501/11/0596, projekt VaV

Název: Epigenetické mechanismy regulace rostlinných telomer (Akronym: epigenetika telomer)

Investor: Grantová agentura ČR, Epigenetické mechanismy regulace rostlinných telomer

IAA500040801, projekt VaV

Název: Telomery a telomerázy: posun od molekulárně-biologického ke strukturně-biologickému přístupu.

Investor: Akademie věd ČR, Telomery a telomerázy: posun od molekulárně-biologického ke strukturně-biologickému přístupu

Citovat

OGROCKÁ, Anna, Eva SÝKOROVÁ, Jiří FAJKUS a Miloslava FOJTOVÁ. Developmental silencing of the AtTERT gene is associated with increased H3K27me3 loading and maintenance of its euchromatic environment. Journal of Experimental Botany. Oxford: OXFORD UNIV PRESS, 2012, roč. 63, č. 11, s. 4233-4241. ISSN 0022-0957. Dostupné z: https://dx.doi.org/10.1093/jxb/ers107.

@article{990384,
   author = {Ogrocká, Anna and Sýkorová, Eva and Fajkus, Jiří and Fojtová, Miloslava},
   article_location = {Oxford},
   article_number = {11},
   doi = {http://dx.doi.org/10.1093/jxb/ers107},
   keywords = {Arabidopsis thaliana; developmental regulation; DNA methylation; histone modifications; telomerase},
   language = {eng},
   issn = {0022-0957},
   journal = {Journal of Experimental Botany},
   title = {Developmental silencing of the AtTERT gene is associated with increased H3K27me3 loading and maintenance of its euchromatic environment},
   url = {http://jxb.oxfordjournals.org/content/63/11/4233},
   volume = {63},
   year = {2012}
}

TY  - JOUR
ID  - 990384
AU  - Ogrocká, Anna - Sýkorová, Eva - Fajkus, Jiří - Fojtová, Miloslava
PY  - 2012
TI  - Developmental silencing of the AtTERT gene is associated with increased H3K27me3 loading and maintenance of its euchromatic environment
JF  - Journal of Experimental Botany
VL  - 63
IS  - 11
SP  - 4233-4241
EP  - 4233-4241
PB  - OXFORD UNIV PRESS
SN  - 00220957
KW  - Arabidopsis thaliana
KW  - developmental regulation
KW  - DNA methylation
KW  - histone modifications
KW  - telomerase
UR  - http://jxb.oxfordjournals.org/content/63/11/4233
L2  - http://jxb.oxfordjournals.org/content/63/11/4233
N2  - elomerase is precisely regulated during development and in animals, involvement of the epigenetic mechanisms to the regulation of the telomerase reverse transcriptase (TERT) gene transcription was reported. In Arabidopsis thaliana model plant, low level of methylated cytosines in the TERT upstream region was detected in both telomerase-positive and telomerase-negative tissues and AtTERT chromatin maintained the euchromatic nature despite the increased H3K27me3 loading in telomerase-negative tissue. These results may reflect a unique attribute of plants – their totipotency - which accords with a reversible and dynamic character of telomerase silencing.
ER  -

OGROCKÁ, Anna, Eva SÝKOROVÁ, Jiří FAJKUS a Miloslava FOJTOVÁ. Developmental silencing of the AtTERT gene is associated with increased H3K27me3 loading and maintenance of its euchromatic environment. \textit{Journal of Experimental Botany}. Oxford: OXFORD UNIV PRESS, 2012, roč.~63, č.~11, s.~4233-4241. ISSN~0022-0957. Dostupné z: https://dx.doi.org/10.1093/jxb/ers107.

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