Common polymorphisms in GSTM1, GSTT1, GSTP1, GSTA1 and
susceptibility to colorectal cancer in the Central European
population

J 2012

Common polymorphisms in GSTM1, GSTT1, GSTP1, GSTA1 and susceptibility to colorectal cancer in the Central European population

HÉŽOVÁ, Renata, Julie BIENERTOVÁ VAŠKŮ, Milana ŠACHLOVÁ, Veronika BŘEZKOVÁ, Anna VAŠKŮ et. al.

Základní údaje

Originální název

Common polymorphisms in GSTM1, GSTT1, GSTP1, GSTA1 and susceptibility to colorectal cancer in the Central European population

Autoři

HÉŽOVÁ, Renata (203 Česká republika), Julie BIENERTOVÁ VAŠKŮ (203 Česká republika, domácí), Milana ŠACHLOVÁ (203 Česká republika), Veronika BŘEZKOVÁ (203 Česká republika), Anna VAŠKŮ (203 Česká republika, domácí), Marek SVOBODA (203 Česká republika), Lenka RADOVÁ (203 Česká republika), Igor KISS (203 Česká republika), Rostislav VYZULA (203 Česká republika) a Ondřej SLABÝ (203 Česká republika, garant, domácí)

Vydání

European Journal of Medical Research, London, Biomed Central, 2012, 0949-2321

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30200 3.2 Clinical medicine

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 1.098

Kód RIV

RIV/00216224:14740/12:00060774

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.1186/2047-783X-17-17

UT WoS

000311309100001

Klíčová slova anglicky

Colorectal cancer; GSTA1; GSTT1; GSTM1; GSTP1; Polymorphism

Štítky

ok, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 23. 4. 2013 08:05, Olga Křížová

Anotace

V originále

Central Europe presents with the highest incidence of sporadic colorectal cancer (CRC) worldwide. As sporadic CRC represents a typical multifactorial disease, it is characterized by intense interaction of the genetic background with the environment. Glutathione Stransferases could act as attractive susceptibility genes for CRC, as they are directly involved in conjugation between glutathione and chemotherapeutics, environmental pollutants and a wide spectrum of xenobiotics. In this study, we investigated associations of polymorphisms in glutathione S-transferases (GSTs) genes, that is GSTA1, GSTT1, GSTM1 and GSTP1, with CRC in a total of 197 cases and 218 controls originating from the Czech Central European population. Polymorphisms were assessed by polymerase chain reaction/restriction fragment length polymorphism-based methods, allele-specific multiplex and allelic discrimination by real-time polymerase chain reaction.

Návaznosti

ED1.1.00/02.0068, projekt VaV

Název: CEITEC - central european institute of technology

Citovat

HÉŽOVÁ, Renata, Julie BIENERTOVÁ VAŠKŮ, Milana ŠACHLOVÁ, Veronika BŘEZKOVÁ, Anna VAŠKŮ, Marek SVOBODA, Lenka RADOVÁ, Igor KISS, Rostislav VYZULA a Ondřej SLABÝ. Common polymorphisms in GSTM1, GSTT1, GSTP1, GSTA1 and susceptibility to colorectal cancer in the Central European population. European Journal of Medical Research. London: Biomed Central, 2012, roč. 17, Jun, s. "nestránkováno", 5 s. ISSN 0949-2321. Dostupné z: https://dx.doi.org/10.1186/2047-783X-17-17.

@article{991016,
   author = {Héžová, Renata and Bienertová Vašků, Julie and Šachlová, Milana and Březková, Veronika and Vašků, Anna and Svoboda, Marek and Radová, Lenka and Kiss, Igor and Vyzula, Rostislav and Slabý, Ondřej},
   article_location = {London},
   article_number = {Jun},
   doi = {http://dx.doi.org/10.1186/2047-783X-17-17},
   keywords = {Colorectal cancer; GSTA1; GSTT1; GSTM1; GSTP1; Polymorphism},
   language = {eng},
   issn = {0949-2321},
   journal = {European Journal of Medical Research},
   title = {Common polymorphisms in GSTM1, GSTT1, GSTP1, GSTA1 and susceptibility to colorectal cancer in the Central European population},
   url = {http://ww.eurjmedres.com/content/17/1/17},
   volume = {17},
   year = {2012}
}

TY  - JOUR
ID  - 991016
AU  - Héžová, Renata - Bienertová Vašků, Julie - Šachlová, Milana - Březková, Veronika - Vašků, Anna - Svoboda, Marek - Radová, Lenka - Kiss, Igor - Vyzula, Rostislav - Slabý, Ondřej
PY  - 2012
TI  - Common polymorphisms in GSTM1, GSTT1, GSTP1, GSTA1 and susceptibility to colorectal cancer in the Central European population
JF  - European Journal of Medical Research
VL  - 17
IS  - Jun
SP  - "nestránkováno"
EP  - "nestránkováno"
PB  - Biomed Central
SN  - 09492321
KW  - Colorectal cancer
KW  - GSTA1
KW  - GSTT1
KW  - GSTM1
KW  - GSTP1
KW  - Polymorphism
UR  - http://ww.eurjmedres.com/content/17/1/17
L2  - http://ww.eurjmedres.com/content/17/1/17
N2  - Central Europe presents with the highest incidence of sporadic colorectal cancer (CRC) worldwide. As sporadic CRC represents a typical multifactorial disease, it is characterized by intense interaction of the genetic background with the environment. Glutathione Stransferases could act as attractive susceptibility genes for CRC, as they are directly involved in conjugation between glutathione and chemotherapeutics, environmental pollutants and a wide spectrum of xenobiotics. In this study, we investigated associations of polymorphisms in glutathione S-transferases (GSTs) genes, that is GSTA1, GSTT1, GSTM1 and GSTP1, with CRC in a total of 197 cases and 218 controls originating from the Czech Central European population. Polymorphisms were assessed by polymerase chain reaction/restriction fragment length polymorphism-based methods, allele-specific multiplex and allelic discrimination by real-time polymerase chain reaction.
ER  -

HÉŽOVÁ, Renata, Julie BIENERTOVÁ VAŠKŮ, Milana ŠACHLOVÁ, Veronika BŘEZKOVÁ, Anna VAŠKŮ, Marek SVOBODA, Lenka RADOVÁ, Igor KISS, Rostislav VYZULA a Ondřej SLABÝ. Common polymorphisms in GSTM1, GSTT1, GSTP1, GSTA1 and susceptibility to colorectal cancer in the Central European population. \textit{European Journal of Medical Research}. London: Biomed Central, 2012, roč.~17, Jun, s.~''nestránkováno'', 5 s. ISSN~0949-2321. Dostupné z: https://dx.doi.org/10.1186/2047-783X-17-17.

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