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@article{991036,
author = {Nováková, Kateřina and Bláha, Luděk and Babica, Pavel},
article_location = {OXFORD, ENGLAND},
article_number = {1},
doi = {http://dx.doi.org/10.1016/j.chemosphere.2012.04.008},
keywords = {Cyanobacteria; Cylindrospermopsin; Gap junctional intercellular communication; Polychlorinated biphenyls; Polycyclic aromatic hydrocarbons; Synergistic effects},
language = {eng},
issn = {0045-6535},
journal = {Chemosphere},
title = {Tumor promoting effects of cyanobacterial extracts are potentiated by anthropogenic contaminants - Evidence from in vitro study.},
volume = {89},
year = {2012}
}
TY - JOUR
ID - 991036
AU - Nováková, Kateřina - Bláha, Luděk - Babica, Pavel
PY - 2012
TI - Tumor promoting effects of cyanobacterial extracts are potentiated by anthropogenic contaminants - Evidence from in vitro study.
JF - Chemosphere
VL - 89
IS - 1
SP - 30-37
EP - 30-37
PB - PERGAMON-ELSEVIER SCIENCE LTD
SN - 00456535
KW - Cyanobacteria
KW - Cylindrospermopsin
KW - Gap junctional intercellular communication
KW - Polychlorinated biphenyls
KW - Polycyclic aromatic hydrocarbons
KW - Synergistic effects
N2 - In the present study we investigated combined effects of anthropogenic environmental contaminants 2,2',4,4',5,5'-hexachlorobiphenyl (PCB 153) and fluoranthene, cyanotoxins microcystin-LR and cylindrospermopsin, and extracts of laboratory cultures of cyanobacteria Aphanizomenon gracile and Cylindrospermopsis raciborskii, on GJIC in the rat liver epithelial cell line WB-F344. Binary mixtures of PCB 153 with fluoranthene and the mixtures of the two cyanobacterial strains elicited simple additive effects on GJIC after 30 min exposure, whereas microcystin-LR and cylindrospermopsin neither inhibited GJIC nor altered effects of PCB 153 or fluoranthene. However, synergistic effects were observed in the cells exposed to binary mixtures of anthropogenic contaminants (PCB 153 or fluoranthene) and cyanobacterial extracts. The synergistic effects were especially pronounced after prolonged (6-24 h) co-exposure to fluoranthene and A. gracile extract, when mixture caused nearly complete GJIC inhibition, while none of the individual components caused any downregulation of GJIC at the same concentration and exposure time. The effects of cyanobacterial extracts were independent of microcystin-LR or cylindrospermopsin, which were not detected in cyanobacterial biomass. It provides further evidence on the presence of unknown tumor promoting metabolites in cyanobacteria. Clear potentiation of the GJIC inhibition observed in the mixtures of two anthropogenic contaminants and cyanobacteria highlight the importance of combined toxic effects of chemicals in complex environmental mixtures.
ER -
NOVÁKOVÁ, Kateřina, Luděk BLÁHA and Pavel BABICA. Tumor promoting effects of cyanobacterial extracts are potentiated by anthropogenic contaminants - Evidence from in vitro study. \textit{Chemosphere}. OXFORD, ENGLAND: PERGAMON-ELSEVIER SCIENCE LTD, 2012, vol.~89, No~1, p.~30-37. ISSN~0045-6535. Available from: https://dx.doi.org/10.1016/j.chemosphere.2012.04.008.
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