Genetics of anti-EHV antibody responses in a horse population

J 2013

Genetics of anti-EHV antibody responses in a horse population

RUSEK, J., Marie KLUMPLEROVÁ, Dobromila MOLINKOVÁ, Markéta SEDLINSKÁ, Ladislav DUŠEK et. al.

Basic information

Original name

Genetics of anti-EHV antibody responses in a horse population

Authors

RUSEK, J. (203 Czech Republic, guarantor), Marie KLUMPLEROVÁ (203 Czech Republic), Dobromila MOLINKOVÁ (203 Czech Republic), Markéta SEDLINSKÁ (203 Czech Republic), Ladislav DUŠEK (203 Czech Republic, belonging to the institution), Jan MUŽÍK (203 Czech Republic, belonging to the institution), Lenka PUTNOVÁ (203 Czech Republic), Irena VRTKOVÁ (203 Czech Republic), Vladimír CELER (203 Czech Republic) and Petr HOŘÍN (203 Czech Republic)

Edition

Research in Veterinary Sciences, Amsterdam, Elsevier, 2013, 0034-5288

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30000 3. Medical and Health Sciences

Country of publisher

Netherlands

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 1.511

RIV identification code

RIV/00216224:14110/13:00068374

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.rvsc.2013.03.011

UT WoS

000320289600022

Keywords in English

Antibody responsiveness; Equine herpes virus; Immunity-related molecular markers; Microsatellites; Statistical associations

Abstract

V originále

Individual variation in immune responses to herpesviruses was observed in various species. Here, associations between polymorphic molecular markers and life-long anti-EHV-1/4 antibody immune responses were analyzed in a model EHV-infected population of the Old Kladruber horses. Two-dimensional analysis including overall mean titers and titer dynamics expressed by differences between spring and autumn titers allowed identification of low-responders. 50 randomly selected microsatellites and nine single nucleotide polymorphisms in nine immunity-related candidate genes were genotyped. Due to differences (p<0.001) in antibody titers between two color varieties of Old Kladruber horses, separate association studies were performed in the two sub-populations by using the Fisher's exact test. In black horses, the interleukin 4 receptor and MxA protein coding genes, and the microsatellite TKY325 were associated with the responder status. In the grey population, the microsatellite TKY343 showed significant association with anti-EHV antibody responsiveness after Bonferroni corrections.

Files attached

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Citovat

RUSEK, J., Marie KLUMPLEROVÁ, Dobromila MOLINKOVÁ, Markéta SEDLINSKÁ, Ladislav DUŠEK, Jan MUŽÍK, Lenka PUTNOVÁ, Irena VRTKOVÁ, Vladimír CELER and Petr HOŘÍN. Genetics of anti-EHV antibody responses in a horse population. Research in Veterinary Sciences. Amsterdam: Elsevier, 2013, Vol. 95, No 1, p. 137-142. ISSN 0034-5288. Available from: https://dx.doi.org/10.1016/j.rvsc.2013.03.011.

@article{1107885,
   author = {Rusek, J. and Klumplerová, Marie and Molinková, Dobromila and Sedlinská, Markéta and Dušek, Ladislav and Mužík, Jan and Putnová, Lenka and Vrtková, Irena and Celer, Vladimír and Hořín, Petr},
   article_location = {Amsterdam},
   article_number = {1},
   doi = {http://dx.doi.org/10.1016/j.rvsc.2013.03.011},
   keywords = {Antibody responsiveness; Equine herpes virus; Immunity-related molecular markers; Microsatellites; Statistical associations},
   language = {eng},
   issn = {0034-5288},
   journal = {Research in Veterinary Sciences},
   title = {Genetics of anti-EHV antibody responses in a horse population},
   volume = {Vol. 95},
   year = {2013}
}

TY  - JOUR
ID  - 1107885
AU  - Rusek, J. - Klumplerová, Marie - Molinková, Dobromila - Sedlinská, Markéta - Dušek, Ladislav - Mužík, Jan - Putnová, Lenka - Vrtková, Irena - Celer, Vladimír - Hořín, Petr
PY  - 2013
TI  - Genetics of anti-EHV antibody responses in a horse population
JF  - Research in Veterinary Sciences
VL  - Vol. 95
IS  - 1
SP  - 137-142
EP  - 137-142
PB  - Elsevier
SN  - 00345288
KW  - Antibody responsiveness
KW  - Equine herpes virus
KW  - Immunity-related molecular markers
KW  - Microsatellites
KW  - Statistical associations
N2  - Individual variation in immune responses to herpesviruses was observed in various species. Here, associations between polymorphic molecular markers and life-long anti-EHV-1/4 antibody immune responses were analyzed in a model EHV-infected population of the Old Kladruber horses. Two-dimensional analysis including overall mean titers and titer dynamics expressed by differences between spring and autumn titers allowed identification of low-responders. 50 randomly selected microsatellites and nine single nucleotide polymorphisms in nine immunity-related candidate genes were genotyped. Due to differences (p<0.001) in antibody titers between two color varieties of Old Kladruber horses, separate association studies were performed in the two sub-populations by using the Fisher's exact test. In black horses, the interleukin 4 receptor and MxA protein coding genes, and the microsatellite TKY325 were associated with the responder status. In the grey population, the microsatellite TKY343 showed significant association with anti-EHV antibody responsiveness after Bonferroni corrections.
ER  -

RUSEK, J., Marie KLUMPLEROVÁ, Dobromila MOLINKOVÁ, Markéta SEDLINSKÁ, Ladislav DUŠEK, Jan MUŽÍK, Lenka PUTNOVÁ, Irena VRTKOVÁ, Vladimír CELER and Petr HOŘÍN. Genetics of anti-EHV antibody responses in a horse population. \textit{Research in Veterinary Sciences}. Amsterdam: Elsevier, 2013, Vol. 95, No~1, p.~137-142. ISSN~0034-5288. Available from: https://dx.doi.org/10.1016/j.rvsc.2013.03.011.

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