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@article{1319699,
author = {Beránková, Dagmar and Janoušová, Eva and Mračková, Martina and Eliášová, Ilona and Košťálová, Milena and Skutilová, Světlana and Rektorová, Irena},
article_location = {New York},
article_number = {579417},
doi = {http://dx.doi.org/10.1155/2015/579417},
keywords = {REVISED ACE-R; DIAGNOSTIC-CRITERIA; IMPAIRMENT; DEMENTIA; VALIDATION; ACCURACY; UTILITY; COHORT},
language = {eng},
issn = {2090-8083},
journal = {Parkinson’s Disease},
title = {Addenbrooke's Cognitive Examination and Individual Domain Cut-Off Scores for Discriminating between Different Cognitive Subtypes of Parkinson's Disease},
url = {http://www.hindawi.com/journals/pd/2015/579417/},
volume = {2015},
year = {2015}
}
TY - JOUR
ID - 1319699
AU - Beránková, Dagmar - Janoušová, Eva - Mračková, Martina - Eliášová, Ilona - Košťálová, Milena - Skutilová, Světlana - Rektorová, Irena
PY - 2015
TI - Addenbrooke's Cognitive Examination and Individual Domain Cut-Off Scores for Discriminating between Different Cognitive Subtypes of Parkinson's Disease
JF - Parkinson’s Disease
VL - 2015
IS - 579417
SP - 1-7
EP - 1-7
PB - Hindawi Publishing Corporation
SN - 20908083
KW - REVISED ACE-R
KW - DIAGNOSTIC-CRITERIA
KW - IMPAIRMENT
KW - DEMENTIA
KW - VALIDATION
KW - ACCURACY
KW - UTILITY
KW - COHORT
UR - http://www.hindawi.com/journals/pd/2015/579417/
N2 - Objective. The main aim of this study was to verify the sensitivity and specificity of Addenbrooke's Cognitive Examination-Revised (ACE-R) in discriminating between Parkinson's disease (PD) with normal cognition (PD-NC) and PD withmild cognitive impairment (PD-MCI) and between PD-MCI and PD with dementia (PD-D). We also evaluated how ACE-R correlates with neuropsychological cognitive tests in PD. Methods. We examined three age-matched groups of PD patients diagnosed according to the Movement Disorder Society Task Force criteria: PD-NC, PD-MCI, and PD-D. ROC analysis was used to establish specific cut-off scores of ACE-R and its domains. Correlation analyses were performed between ACE-R and its subtests with relevant neuropsychological tests. Results. Statistically significant differences between groups were demonstrated in global ACE-R scores and subscores, except in the language domain. ACE-R cut-off score of 88.5 points discriminated best between PD-MCI and PD-NC (sensitivity 0.68, specificity 0.91); ACE-R of 82.5 points distinguished best between PD-MCI and PD-D (sensitivity 0.70, specificity 0.73). The verbal fluency domain of ACE-R demonstrated the best discrimination between PD-NC and PD-MCI (cut-off score 11.5; sensitivity 0.70, specificity 0.73) while the orientation/attention subscore was best between PD-MCI and PD-D (cut-off score 15.5; sensitivity 0.90, specificity 0.97). ACE-R scores except for ACE-R language correlated with specific cognitive tests of interest.
ER -
BERÁNKOVÁ, Dagmar, Eva JANOUŠOVÁ, Martina MRAČKOVÁ, Ilona ELIÁŠOVÁ, Milena KOŠŤÁLOVÁ, Světlana SKUTILOVÁ a Irena REKTOROVÁ. Addenbrooke's Cognitive Examination and Individual Domain Cut-Off Scores for Discriminating between Different Cognitive Subtypes of Parkinson's Disease. \textit{Parkinson’s Disease}. New York: Hindawi Publishing Corporation, 2015, roč.~2015, č.~579417, s.~1-7. ISSN~2090-8083. Dostupné z: https://dx.doi.org/10.1155/2015/579417.
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