Thesis/Dissertation: Mgr. Tereza Váňová, učo 269906: Regulation of cell fate decisions in human pluripotent stem cells by manipulation with FGF2 signaling
Doctoral thesis
Regulation of cell fate decisions in human pluripotent stem cells by manipulation with FGF2 signaling
Regulace diferenciace lidských pluripotentních kmenových buněk manipulací signálování FGF2
Abstract
Lidské pluripotentní kmenové buňky (PSCs) jsou in vitro udržovány v nediferencovaném stavu exogenně přidávaným fibroblastovým růstovým faktorem (FGF2). Lidské PSCs samy produkují FGF2, který je sekretován do extracelulárního prostoru, kde spouští autokrinní/parakrinní signalizaci. V první části své disertační práce jsem analyzovala, zda je sekrece FGF2 z lidských PSCs spojena s aktivitou tyrosin kinázy …more
Abstract
Human pluripotent stem cells (PSCs) are in vitro maintained in undifferentiated state by exogenously administered fibroblast growth factor 2 (FGF2). Human PSCs also produce FGF2, which is secreted into extracellular space to trigger autocrine/paracrine signaling. In the first part of my thesis I analyzed possible connection between FGF2 secretion from human PSCs and activity of tyrosine kinase expressed …more
21/2/2018 14:39, prof. Ing. Petr Dvořák, CSc., UČO 47260
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