Master's thesis

Effects of newly synthesized compounds on the activity of intestinal microbial communities

Vanina Nikolaeva
Abstract

The master’s thesis aims to determine the minimum inhibitory concentration of newly synthesized substances and their effect, either inhibitory or stimulating, on the physiological properties of selected bacterial genera. A minimum inhibitory concentration is the lowest concentration at which an antimicrobial agent inhibits the visible growth of a bacterial culture. The Proteobacteria phylum, more specifically …more

Abstract

The master’s thesis aims to determine the minimum inhibitory concentration of newly synthesized substances and their effect, either inhibitory or stimulating, on the physiological properties of selected bacterial genera. A minimum inhibitory concentration is the lowest concentration at which an antimicrobial agent inhibits the visible growth of a bacterial culture. The Proteobacteria phylum, more specifically …more

Keywords
Minimální inhibiční koncentrace enterobakterie mikrobicidy idiopatické střevní záněty Crohnova nemoc ulcerózní kolitida mikrobiom S. typhimurium E. coli Minimum inhibitory concentration enterobacteria antibacterial agents inflammatory bowel diseases Crohn’s disease ulcerative colitis
Thesis description
The number of patients diagnosed with nonspecific intestinal inflammation is increasing every year. These patients often have an increased number of certain genera of intestinal bacteria that may play a role in the development of this disease. Frequent use of antibiotics in treatment leads to the development of resistance in these bacteria and therefore to its inefficiency. Therefore, it is necessary to search for new active substances, test their activity and possible potential for use in therapy. The aim of this work is to determine the minimum inhibitory concentrations (MIC) of newly synthesized substances and their effect on the physiological properties of selected bacterial genera as well as to propose the possible use of promising compounds in the treatment of intestinal inflammation.
Administrative information
The thesis has been checked:
16/6/2023 14:10, doc. Ivan Kushkevych, Ph.D., UČO 238729
Full text of thesis
4,4 MB / file PDF
Language used
English English
Defence date
20/6/2023
The thesis was defended successfully

Supervisor

doc. Ivan Kushkevych, Ph.D., UČO 238729
Mikrob ÚEB Biol PřF MU

Readers

Josef Jampílek
The author of the thesis report has not been identified yet.

Literature

  • KUSHKEVYCH, Ivan; Monika VÍTĚZOVÁ; Jiri KOS; Peter KOLLÁR and Josef JAMPI­LEK. Effect of selected 8-hydroxyquinoline-2-carboxanilides on viability and sulfate metabolism of Desulfovibrio piger. Journal of Applied Biomedicine. Jihočeská univerzita v Českých Budějovicích, 2018, vol. 16, No 3, p. 241-246. ISSN 1214-021X. Available from: https://doi.org/10.1016/j.jab.2018.01.004.
  • KUSHKEVYCH, Ivan; Oľga LEŠČANOVÁ; Dani DORDEVIĆ; Simona JANČÍKOVÁ; Jan HOŠEK; Monika VÍTĚZOVÁ; Leona BUŇKOVÁ and Lorenzo DRAGO. The Sulfate-Reducing Microbial Communities and Meta-Analysis of Their Occurrence during Diseases of Small–Large Intestine Axis. Journal of Clinical Medicine. BASEL: MDPI, 2019, vol. 8, No 10, p. 1-12. ISSN 2077-0383. Available from: https://doi.org/10.3390/jcm8101656.
Cite this text
Masaryk University Faculty of Science
Programme
Plan
Molecular and Cell Biology

Theses on a related topic

List of theses with an identical keyword.

Similar documents

  • Přidání souboru

    Soubor nebo složku lze nahrát pomocí tlačítka Přidat.

  • Další operace se soubory

    Podrobnosti lze zjistit označením příslušného řádku.

  • Pohled pro experty

    Pro častou práci je možné zvolit režim Více možností.

  • Vyhledávání souborů

    Vyhledávaný výraz můžete zadat přímo do adresního řádku.

  • Rychlý přístup k souborům

    Pomocí funkce Nedávné je možné se rychle vrátit k právě prohlíženým souborům. Oblíbené soubory je také možné označit Hvězdičkou.