The goal of this work is to prepare data models describing structured and relevant patient data for the purpose of further analysis and research performed in cooperation with medical partners in THALAMOSS (EU project 7FP) and BBMRI_CZ (Large Infrastructure within the Czech Republic) projects. Data management architecture and implementation of patient information acquisition and retrieval tools will be proposed. The architecture has to satisfy the requirements posed on patient data management on the European and national level for THALAMOSS and BBMRI_CZ, respectively. The management tools can make use of third party off-the-shelf components, e.g., bioinformatical data storage systems. End-user tools may be implemented using portal technologies, especially for data access, as well as standalone application or applications built on Microsoft Office to ease their deployment in medical and hospital environment.