The course provides an overview of the current knowledge of molecular biology, genetics and human genetics in the context of other theoretical branches of the Faculty of Medicine. Recent concepts of developmental biology and ontogeny, cell signalling, structural and epigenetic changes in the DNA, cancer biology, gene therapy and bioinformatics are discussed. The subject matter presented in this course will help to better understanding of other subjects including physiology, pathology and human and clinical genetics.

Syllabus

1st week: 18.-22.2. 2013 Lecture: Introduction to developmental biology 2nd week: 25.2. – 1.3.2013 Lecture: Basic principles and molecular mechanisms regulating early development of mammals – physiology and pathology 3rd week: 4. – 8.3.2013 Lecture: Biology and use of stem cells in disease modelling and cell therapy 4th week: 11. – 15.3.2013 Lecture: Growth factors and signal transduction in development and disease 5th week: 18. – 22.3.2013 Lecture: Genome instability - from molecular mechanisms of damage and DNA repair to clinical implications 6th week: 25. – 29.3.2013 Lecture: Molecular principle of genetic diseases 7th week: 1. – 5.4.2013 Lecture: Introduction to cancer biology 8th week: 8. – 12.4.2013 Lecture: Oncogenes and oncoviruses in cancer transformation 9th week: 15. – 19.4.2013 Lecture: Tumour supressor genes – implications for diagnostics and therapy 10th week: 22. – 26.4.2013 Lecture: Paradigm of cancer stem cells 11th week: 29.4. – 3.5.2013 Lecture: Objectives and strategies of molecular therapy 12th week: 6. – 10.5.2013 Lecture: Bioinformatics in medicine – from molecules to populations 13th week: 13. – 17.5.2013 Lecture: Milestones in biological sciences in context with advances in clinical medicine 14th week: 20. – 24.5.2013 Lecture: Advances in molecular, cell or developmental biology with regard to biomedicine - „Breakthrough of the Year 2012“

Literature

recommended literature

ALBERTS, Bruce. Základy buněčné biologie :úvod do molekulární biologie buňky. Translated by Arnošt Kotyk. 2. vyd. Ústí nad Labem: Espero Publishing, 2006. xxvi, 630. ISBN 80-902906-2-0. info
Essential cell biology. Edited by Bruce Alberts. 3rd ed. New York: Garland Science, 2009. 1 v. (vari. ISBN 978-0-8153-4130. info
CAMPBELL, Neil A. and Jane B. REECE. Biologie. Vyd. 1. Brno: Computer Press, 2006. xxxiv, 133. ISBN 80-251-1178-4. info
CAMPBELL, Neil A. and Jane B. REECE. Biology. 7th ed. San Francisco: Pearson/Benjamin Cummings, 2005. xl, 1231 s. ISBN 0-8053-7146-X. info
SNUSTAD, D. Peter, Michael J. SIMMONS, Jiřina RELICHOVÁ, Jiří DOŠKAŘ, Jiří FAJKUS, Petr HOŘÍN, Aleš KNOLL, Petr KUGLÍK, Jan ŠMARDA, Jana ŠMARDOVÁ, Renata VESELSKÁ and Boris VYSKOT. Genetika (Principles of Genetics). 1. vyd. Brno: Masarykova univerzita, 2009. 894 pp. Učebnice. ISBN 978-80-210-4852-2. URL info
Principles of genetics. Edited by D. Peter Snustad - Michael J. Simmons. 5th ed. Hoboken: John Wiley & Sons, Inc, 2009. xix, 823 s. ISBN 9780470388259. info
Základy lékařské genetiky. Edited by D. J. Pritchard - Bruce R. Korf. 1. vyd. Praha: Galén, 2007. 182 s. ISBN 978-80-7262-449. info
HARDIN, Jeff, Gregory BERTONI and Lewis J. KLEINSMITH. Becker's world of the cell. 8th ed. Boston: Benjamin Cummings, 2012. xxviii, 79. ISBN 0321689631. info
JANISCH, Roman. Overview of General Biology (Overview of General Biology). 2. rozšířené. Brno: Masarykova univerzita, 2010. 91 pp. ISBN 978-80-210-5187-4. info
LODISH, Harvey F. Molecular cell biology. 6th ed. New York, N.Y.: W.H. Freeman and Company, 2008. xxxvii, 11. ISBN 978-0-7167-7601. info
Pollard, Thomas D., Earnshaw, William C.: Cell Biology, 2nd edition, Saunders 2007. ISBN: 978-1-4160-2255-8
Principles of development. Edited by Lewis Wolpert. 2nd ed. Oxford: Oxford University Press, 2002. xxv, 542 s. ISBN 0-19-879291-3. info

Teaching methods